FOG02122
EOG8KSN1S

sce:GEP4

Genes: 31

SGD Description
Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT


PomBase Description
mitochondrial matrix PGP phosphatase involved in cardiolipin biosynthesis Gep4 (predicted)


AspGD Description
Ortholog(s) have phosphatidylglycerophosphatase activity, role in cardiolipin biosynthetic process, phosphorylated carbohydrate dephosphorylation and mitochondrial matrix localization


References

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Osman C, et al. (2009 Feb 23). The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria.

Osman C, et al. (2010 Jun 16). A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%