FOG02116
EOG8FXPRD

sce:GDE1

Genes: 30

SGD Description
Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes


PomBase Description
glycerophosphoryl diester phosphodiesterase Gde1 (predicted)


AspGD Description
Ortholog(s) have glycerophosphocholine phosphodiesterase activity, role in cellular response to drug, glycerophospholipid catabolic process and cytosol, ribosome localization


References

Fernández-Murray JP, et al. (2005 Nov 18). Glycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.

Fisher E, et al. (2005 Oct 28). Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Garg A, et al. (2015 Aug 18). A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG02117
EOG8FXPRD

sce:PHO81

Genes: 31

SGD Description
Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress


AspGD Description
Ortholog(s) have cyclin-dependent protein serine/threonine kinase inhibitor activity


References

Coche T, et al. (1990 Apr 25). Nucleotide sequence of the PHO81 gene involved in the regulation of the repressible acid phosphatase gene in Saccharomyces cerevisiae.

Ogawa N, et al. (1993 Apr). Promoter analysis of the PHO81 gene encoding a 134 kDa protein bearing ankyrin repeats in the phosphatase regulon of Saccharomyces cerevisiae.

Creasy CL, et al. (1993 Apr 25). Molecular analysis of the PHO81 gene of Saccharomyces cerevisiae.

Hirst K, et al. (1994 Nov 15). The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal.

Schneider KR, et al. (1994 Oct 7). Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the CDK inhibitor PHO81.

Lee M, et al. (2000 Oct). Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81.

Knight JP, et al. (2004 Jul). Regulation by phosphorylation of Pho81p, a cyclin-dependent kinase inhibitor in Saccharomyces cerevisiae.

Waters NC, et al. (2004 Jul). The yeast Pho80-Pho85 cyclin-CDK complex has multiple substrates.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG02118
EOG8FXPRD

sce:absent

Genes: 6

AspGD Description
Ortholog of A. fumigatus Af293 : Afu6g04960, A. oryzae RIB40 : AO090701000042, Neosartorya fischeri NRRL 181 : NFIA_051520 and Aspergillus wentii : Aspwe1_0327865|Protein of unknown function|Has domain(s) with predicted glycerophosphodiester phosphodiesterase activity, phosphoric diester hydrolase activity and role in glycerol metabolic process, lipid metabolic process|Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%