FOG02103
EOG8MGQQJ
EOG8THT84

sce:PLB1;PLB2;PLB3

Genes: 69

SGD Description
Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication|Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine|Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication


PomBase Description
phospholipase (predicted)|phospholipase B homolog Plb1


AspGD Description
Putative lysophospholipase phospholipase B; induced by caspofungin|Ortholog(s) have cytosol, endoplasmic reticulum, nucleus localization|Has domain(s) with predicted phospholipase activity and role in metabolic process, phospholipid catabolic process|Ortholog(s) have lysophospholipase activity, role in phosphatidylcholine acyl-chain remodeling and anchored component of plasma membrane, endoplasmic reticulum, periplasmic space localization


References

Lee KS, et al. (1994 Aug 5). The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity.

Hoover CI, et al. (1998 Oct 15). Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene.

Leidich SD, et al. (1998 Oct 2). Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans.

Oishi H, et al. (1999 Jan). Purification and characterization of phospholipase B from Kluyveromyces lactis, and cloning of phospholipase B gene.

Hamada K, et al. (1999 Jul). Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins.

Fyrst H, et al. (1999 May 4). The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase.

Merkel O, et al. (1999 Oct 1). Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae.

Yang P, et al. (2003 Apr). The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Guydosh NR, et al. (2017 Sep 25). Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in <i>S. pombe</i>.

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 37 genes with posterior transmembrane prediction > 50%

FOG02104
EOG8MGQQJ
EOG8THT84

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02105
EOG8THT84

sce:absent

Genes: 5

AspGD Description
Phospholipase A2

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG02106
EOG8D2554
EOG8MGQQJ

sce:SPO1

Genes: 18

SGD Description
Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B


References

Tevzadze GG, et al. (1996 Oct 24). The SPO1 gene product required for meiosis in yeast has a high similarity to phospholipase B enzymes.

Tevzadze GG, et al. (2000). Spo1, a phospholipase B homolog, is required for spindle pole body duplication during meiosis in Saccharomyces cerevisiae.

Davis CA, et al. (2000 Apr 15). Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.

Tevzadze GG, et al. (2007 Mar). Genetic evidence for a SPO1-dependent signaling pathway controlling meiotic progression in yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%

FOG02107
EOG8MGQQJ

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted phospholipase activity and role in metabolic process, phospholipid catabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%