FOG02059
EOG8C5B1X

sce:ARH1

Genes: 33

SGD Description
Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability


PomBase Description
NADPH-adrenodoxin reductase Arh1


AspGD Description
Ortholog(s) have NADP binding, NADPH-adrenodoxin reductase activity, ferredoxin-NADP+ reductase activity, flavin adenine dinucleotide binding activity and mitochondrion localization


References

Nobrega FG, et al. (1992 Nov). BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae.

Lacour T, et al. (1996 Oct 3). A gene encoding a yeast equivalent of mammalian NADPH-adrenodoxin oxidoreductases.

Manzella L, et al. (1998 Jun 30). ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase.

Ewen KM, et al. (2008 May). The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe.

Müller JJ, et al. (2011 Jul). Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Paul A, et al. (2017 Oct 5). FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%