FOG02043
EOG8G1K2D

sce:SOD1

Genes: 31

SGD Description
Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS and complements yeast null; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex


PomBase Description
superoxide dismutase Sod1


AspGD Description
Cu,Zn superoxide dismutase; repressed by growth on starch and lactate


References

Steinman HM, et al. (1980 Jul 25). The amino acid sequence of copper-zinc superoxide dismutase from bakers' yeast.

Bermingham-McDonogh O, et al. (1988 Jul). The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity.

Djinović K, et al. (1991 Dec 1). Structure solution and molecular dynamics refinement of the yeast Cu,Zn enzyme superoxide dismutase.

Djinovic K, et al. (1992 Jun 5). Crystal structure of yeast Cu,Zn superoxide dismutase. Crystallographic refinement at 2.5 A resolution.

Holdom MD, et al. (1996 Aug). The Cu,Zn superoxide dismutases of Aspergillus flavus, Aspergillus niger, Aspergillus nidulans, and Aspergillus terreus: purification and biochemical comparison with the Aspergillus fumigatus Cu,Zn superoxide dismutase.

Ogihara NL, et al. (1996 Feb 20). Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.

Hernández-Saavedra NY, et al. (1998 Apr 30). Cloning and sequencing of a cDNA encoding a copper-zinc superoxide dismutase enzyme from the marine yeast Debaryomyces hansenii.

Hart PJ, et al. (1999 Feb 16). A structure-based mechanism for copper-zinc superoxide dismutase.

Oberegger H, et al. (2000 Nov 24). Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus.

Jeong JH, et al. (2001 May 18). Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.

Sturtz LA, et al. (2001 Oct 12). A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

Lamb AL, et al. (2001 Sep). Heterodimeric structure of superoxide dismutase in complex with its metallochaperone.

Oberegger H, et al. (2001 Sep). SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans.

Oberegger H, et al. (2002 Aug). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization.

Lee YY, et al. (2002 Aug 31). Regulation of Schizosaccharomyces pombe gene encoding copper/zinc superoxide dismutase.

Mutoh N, et al. (2002 May). Characterization of Cu, Zn-superoxide dismutase-deficient mutant of fission yeast Schizosaccharomyces pombe.

Lee J, et al. (2002 Oct 4). Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.

Eisendle M, et al. (2003 Jul). The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding l-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC).

Haas H, et al. (2003 Sep). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage.

Carroll MC, et al. (2004 Apr 20). Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone.

Zhou W, et al. (2004 Jul 30). Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses.

Jensen LT, et al. (2005 Dec 16). Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.

Pócsi I, et al. (2005 Dec 20). Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Tribus M, et al. (2005 Oct). HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress.

Kwon ES, et al. (2006 Jan 20). Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe.

Tarhan C, et al. (2007 Dec). The effect of superoxide dismutase deficiency on zinc toxicity in Schizosaccharomyces pombe.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Jara M, et al. (2007 Jun). The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

Mutoh N, et al. (2007 Nov). Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having cu and zn as cofactors and its enhancement by sir2 deficiency.

Roux AE, et al. (2009 Mar). Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Paul SK, et al. (2009 Sep). A large complex mediated by Moc1, Moc2 and Cpc2 regulates sexual differentiation in fission yeast.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.

Plante S, et al. (2014 Apr 4). Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Wang Y, et al. (2014 Oct). The role of frataxin in fission yeast iron metabolism: implications for Friedreich's ataxia.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Ogata T, et al. (2016 Jan). Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeast Schizosaccharomyces pombe.

Pluskal T, et al. (2016 Jun). Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions.

Plante S, et al. (2017 Jul 14). Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG02044
EOG8G1K2D

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%