FOG01961
EOG8KH1B2

sce:HEM13

Genes: 34

SGD Description
Coproporphyrinogen III oxidase; an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)


PomBase Description
coproporphyrinogen III oxidase Hem13 (predicted)


AspGD Description
Coproporphyrinogen III oxidase (coproporphyrinogenase)


References

Camadro JM, et al. (1986 May 2). Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae.

Zagorec M, et al. (1988 Jul 15). Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase.

Phillips JD, et al. (2004 Sep 10). Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.

Hughes AL, et al. (2005 Mar 25). SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.

Todd BL, et al. (2006 Apr). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Lee CY, et al. (2011 Oct 21). Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Brookheart RT, et al. (2014 Jan 31). Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.

Singh A, et al. (2017 Nov). Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%