FOG01919
EOG8MW6N2
sce:PMT2;PMT3
Genes: 35
EOG8MW6N2
sce:PMT2;PMT3
Genes: 35
Protein description
PTM6
SGD Description
Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication|Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication
PomBase Description
protein O-mannosyltransferase Ogm2
AspGD Description
Ortholog(s) have dolichyl-phosphate-mannose-protein mannosyltransferase activity
References
Gentzsch M, et al. (1995 Dec 18). Protein O-glycosylation in Saccharomyces cerevisiae: the protein O-mannosyltransferases Pmt1p and Pmt2p function as heterodimer.
Lussier M, et al. (1995 Feb 10). Protein O-glycosylation in yeast. The PMT2 gene specifies a second protein O-mannosyltransferase that functions in addition to the PMT1-encoded activity.
Immervoll T, et al. (1995 Nov). PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae.
Gentzsch M, et al. (1996 Nov 1). The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital.
Gentzsch M, et al. (1997 Jun). Protein-O-glycosylation in yeast: protein-specific mannosyltransferases.
Momany M, et al. (1999 Feb). Aspergillus nidulans swo mutants show defects in polarity establishment, polarity maintenance and hyphal morphogenesis.
Momany M, et al. (2002 Dec). Polarity in filamentous fungi: establishment, maintenance and new axes.
Shaw BD, et al. (2002 Dec). Aspergillus nidulans polarity mutant swoA is complemented by protein O-mannosyltransferase pmtA.
Girrbach V, et al. (2003 Apr 4). Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves.
Oka T, et al. (2004 Jun). Molecular characterization of protein O-mannosyltransferase and its involvement in cell-wall synthesis in Aspergillus nidulans.
Nakatsukasa K, et al. (2004 Nov 26). Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast.
Momany M, et al. (2004 Oct). The Aspergillus fumigatus cell wall is organized in domains that are remodelled during polarity establishment.
Rouabhia M, et al. (2005 Aug). Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Prill SK, et al. (2005 Jan). PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.
Willer T, et al. (2005 Jul). Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.
Momany M, et al. (2005 May). Growth control and polarization.
Tanaka N, et al. (2005 May 13). Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe.
Oka T, et al. (2005 Nov). Protein O-mannosyltransferase A of Aspergillus awamori is involved in O-mannosylation of glucoamylase I.
Insenser M, et al. (2006 Apr). Proteomic analysis of detergent-resistant membranes from Candida albicans.
Vajsar J, et al. (2006 Aug 3). Walker-Warburg syndrome.
Castillo L, et al. (2006 Feb). Genomic response programs of Candida albicans following protoplasting and regeneration.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Hirayama H, et al. (2008 Apr). O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Goto M, et al. (2009 Oct). Protein O-mannosyltransferases B and C support hyphal development and differentiation in Aspergillus nidulans.
Kriangkripipat T, et al. (2009 Oct). Aspergillus nidulans protein O-mannosyltransferases play roles in cell wall integrity and developmental patterning.
Mircus G, et al. (2009 Oct). Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant.
Goder V, et al. (2011 Jan 1). Protein O-mannosyltransferases participate in ER protein quality control.
Arroyo J, et al. (2011 Mar). Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast.
Cantero PD, et al. (2011 May). Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.
Wang L, et al. (2012). Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Kriangkripipat T, et al. (2014). Aspergillus nidulans Pmts form heterodimers in all pairwise combinations.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
35 genes with posterior transmembrane prediction > 50% |
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FOG01920
EOG8MW6N2
sce:PMT1;PMT5
Genes: 36
EOG8MW6N2
sce:PMT1;PMT5
Genes: 36
SGD Description
Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen|Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
PomBase Description
protein O-mannosyltransferase Ogm1
AspGD Description
Ortholog(s) have dolichyl-phosphate-mannose-protein mannosyltransferase activity
References
Strahl-Bolsinger S, et al. (1993 Sep 1). PMT1, the gene for a key enzyme of protein O-glycosylation in Saccharomyces cerevisiae.
Gentzsch M, et al. (1995 Dec 18). Protein O-glycosylation in Saccharomyces cerevisiae: the protein O-mannosyltransferases Pmt1p and Pmt2p function as heterodimer.
Gentzsch M, et al. (1996 Nov 1). The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital.
Timpel C, et al. (1998 Aug 14). Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans.
Bourdineaud JP, et al. (1998 Jan). Pmt1 mannosyl transferase is involved in cell wall incorporation of several proteins in Saccharomyces cerevisiae.
Strahl-Bolsinger S, et al. (1999 Mar 26). Transmembrane topology of pmt1p, a member of an evolutionarily conserved family of protein O-mannosyltransferases.
Girrbach V, et al. (2000 Jun 23). Structure-function analysis of the dolichyl phosphate-mannose: protein O-mannosyltransferase ScPmt1p.
Girrbach V, et al. (2003 Apr 4). Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves.
Weber Y, et al. (2004 Oct). Pmt-mediated O mannosylation stabilizes an essential component of the secretory apparatus, Sec20p, in Candida albicans.
Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.
Rouabhia M, et al. (2005 Aug). Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Prill SK, et al. (2005 Jan). PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.
Willer T, et al. (2005 Jul). Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.
Tanaka N, et al. (2005 May 13). Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe.
Vajsar J, et al. (2006 Aug 3). Walker-Warburg syndrome.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Peltroche-Llacsahuanga H, et al. (2006 Oct). Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
Hirayama H, et al. (2008 Apr). O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.
de Boer AD, et al. (2010 Aug). The Candida albicans cell wall protein Rhd3/Pga29 is abundant in the yeast form and contributes to virulence.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Goder V, et al. (2011 Jan 1). Protein O-mannosyltransferases participate in ER protein quality control.
Cantero PD, et al. (2011 May). Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.
Lommel M, et al. (2011 Nov 18). A conserved acidic motif is crucial for enzymatic activity of protein O-mannosyltransferases.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
36 genes with posterior transmembrane prediction > 50% |
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FOG01921
EOG8MW6N2
sce:PMT4
Genes: 32
EOG8MW6N2
sce:PMT4
Genes: 32
Protein description
PMT4
SGD Description
Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
PomBase Description
protein O-mannosyltransferase Ogm4
AspGD Description
Putative O-mannosyltransferase; expression enhanced by maltose
References
Immervoll T, et al. (1995 Nov). PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae.
Gentzsch M, et al. (1996 Nov 1). The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital.
Gentzsch M, et al. (1997 Jun). Protein-O-glycosylation in yeast: protein-specific mannosyltransferases.
Sanders SL, et al. (1999 Jun 14). O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells.
Girrbach V, et al. (2003 Apr 4). Members of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves.
Proszynski TJ, et al. (2004 Apr). O-glycosylation as a sorting determinant for cell surface delivery in yeast.
Lommel M, et al. (2004 Jan). Aberrant processing of the WSC family and Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-mannosylation mutants.
Weber Y, et al. (2004 Oct). Pmt-mediated O mannosylation stabilizes an essential component of the secretory apparatus, Sec20p, in Candida albicans.
Rouabhia M, et al. (2005 Aug). Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Prill SK, et al. (2005 Jan). PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.
Willer T, et al. (2005 Jul). Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast.
Tanaka N, et al. (2005 May 13). Characterization of O-mannosyltransferase family in Schizosaccharomyces pombe.
Vajsar J, et al. (2006 Aug 3). Walker-Warburg syndrome.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Peltroche-Llacsahuanga H, et al. (2006 Oct). Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.
Imai K, et al. (2007 Jan). Peculiar protein-protein interactions of the novel endoplasmic reticulum membrane protein Rcr1 and ubiquitin ligase Rsp5.
Hutzler J, et al. (2007 May 8). Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases.
Goto M, et al. (2009 Oct). Protein O-mannosyltransferases B and C support hyphal development and differentiation in Aspergillus nidulans.
Kriangkripipat T, et al. (2009 Oct). Aspergillus nidulans protein O-mannosyltransferases play roles in cell wall integrity and developmental patterning.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Cantero PD, et al. (2011 May). Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.
Srikantha T, et al. (2013 Jun). Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.
Kriangkripipat T, et al. (2014). Aspergillus nidulans Pmts form heterodimers in all pairwise combinations.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Larson A, et al. (2016 Jun 1). Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
32 genes with posterior transmembrane prediction > 50% |
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FOG01922
EOG8MW6N2
sce:absent
Genes: 2
EOG8MW6N2
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG01923
EOG8MW6N2
sce:PMT6
Genes: 23
EOG8MW6N2
sce:PMT6
Genes: 23
SGD Description
Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
References
Gentzsch M, et al. (1997 Jun). Protein-O-glycosylation in yeast: protein-specific mannosyltransferases.
Timpel C, et al. (2000 Jun). Morphogenesis, adhesive properties, and antifungal resistance depend on the Pmt6 protein mannosyltransferase in the fungal pathogen candida albicans.
Rouabhia M, et al. (2005 Aug). Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.
Hirayama H, et al. (2008 Apr). O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.
Singh RP, et al. (2011 Jul 15). Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Srikantha T, et al. (2013 Jun). Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/α biofilms.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
23 genes with posterior transmembrane prediction > 50% |
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FOG01924
EOG8MW6N2
sce:absent
Genes: 8
EOG8MW6N2
sce:absent
Genes: 8
References
Rouabhia M, et al. (2005 Aug). Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Prill SK, et al. (2005 Jan). PMT family of Candida albicans: five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
8 genes with posterior transmembrane prediction > 50% |
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