FOG01866
EOG8PNW1C

sce:RAM2

Genes: 34

Protein description
Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I


SGD Description
Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (RAM2-RAM1 heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (RAM2-CDC43 heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor


PomBase Description
geranylgeranyltransferase I and farnesyltransferase alpha subunit Cwp1


AspGD Description
Ortholog(s) have CAAX-protein geranylgeranyltransferase activity, protein farnesyltransferase activity


References

He B, et al. (1991 Dec 15). RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.

Díaz M, et al. (1993 Dec 15). The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis.

Burkett TJ, et al. (1994 Jan). Molecular characterization of the SPT23 gene: a dosage-dependent suppressor of Ty-induced promoter mutations from Saccharomyces cerevisiae.

Arellano M, et al. (1998 Sep). Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe.

Yang W, et al. (2000 Jan 7). Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.

Dyer PS, et al. (2003 Sep). Genomics reveals sexual secrets of Aspergillus.

Nakase Y, et al. (2006 Jun). A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%