FOG01841
EOG8WDBSN
sce:MYO2;MYO4
Genes: 34
EOG8WDBSN
sce:MYO2;MYO4
Genes: 34
SGD Description
Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication|Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication
PomBase Description
myosin type V
AspGD Description
Ortholog(s) have actin filament binding, calmodulin binding, microfilament motor activity
References
Johnston GC, et al. (1991 May). The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.
Haarer BK, et al. (1994 Apr). Identification of MYO4, a second class V myosin gene in yeast.
Brockerhoff SE, et al. (1994 Feb). The unconventional myosin, Myo2p, is a calmodulin target at sites of cell growth in Saccharomyces cerevisiae.
Lillie SH, et al. (1994 May). Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae.
Stevens RC, et al. (1998 Aug 10). Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae.
Catlett NL, et al. (1998 Dec 8). The terminal tail region of a yeast myosin-V mediates its attachment to vacuole membranes and sites of polarized growth.
Münchow S, et al. (1999 May). Association of the class V myosin Myo4p with a localised messenger RNA in budding yeast depends on She proteins.
Robinson NG, et al. (1999 May). Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70.
Yin H, et al. (2000 Aug 31). Myosin V orientates the mitotic spindle in yeast.
Catlett NL, et al. (2000 Aug 7). Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.
Long RM, et al. (2000 Dec 1). She2p is a novel RNA-binding protein that recruits the Myo4p-She3p complex to ASH1 mRNA.
Beningo KA, et al. (2000 Feb). The yeast kinesin-related protein Smy1p exerts its effects on the class V myosin Myo2p via a physical interaction.
Takizawa PA, et al. (2000 May 9). The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p.
Böhl F, et al. (2000 Oct 16). She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p.
Rossanese OW, et al. (2001 Apr 2). A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae.
Hoepfner D, et al. (2001 Dec 10). A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.
Win TZ, et al. (2001 Jan). Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo51 is a component of the cytokinetic actin ring.
Reck-Peterson SL, et al. (2001 May 28). The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors.
Wagner W, et al. (2002 Dec 2). Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p.
Kruse C, et al. (2002 Dec 23). Ribonucleoprotein-dependent localization of the yeast class V myosin Myo4p.
Schott DH, et al. (2002 Jan 7). Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm length.
Itoh T, et al. (2002 Nov). Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.
Terrak M, et al. (2002 Oct). Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V.
Wesche S, et al. (2003 Apr 29). The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.
Langkjaer RB, et al. (2003 Feb 20). Yeast genome duplication was followed by asynchronous differentiation of duplicated genes.
Terrak M, et al. (2003 Feb 3). Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications.
Ishikawa K, et al. (2003 Mar 17). Identification of an organelle-specific myosin V receptor.
Hwang E, et al. (2003 May 12). Spindle orientation in Saccharomyces cerevisiae depends on the transport of microtubule ends along polarized actin cables.
Itoh T, et al. (2004 Jul 7). Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast.
Gonsalvez GB, et al. (2004 Oct 29). ASH1 mRNA anchoring requires reorganization of the Myo4p-She3p-She2p transport complex.
Gangar A, et al. (2005 Jun 21). Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function.
Martín-García R, et al. (2006 Jul 1). The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.
Mulvihill DP, et al. (2006 Mar). A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe.
Grallert A, et al. (2007 Dec 1). In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain.
Das M, et al. (2009 Aug 11). The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.
Amorim MJ, et al. (2009 Feb). Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally.
Aydar E, et al. (2009 Jun). Polycystic kidney disease channel and synaptotagmin homologues play roles in schizosaccharomyces pombe cell wall synthesis/repair and membrane protein trafficking.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.
Martín-García R, et al. (2009 Nov 1). Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
Clayton JE, et al. (2010 Aug 24). Differential regulation of unconventional fission yeast myosins via the actin track.
Mata J, et al. (2010 Feb). Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites.
Heuck A, et al. (2010 May 3). The structure of the Myo4p globular tail and its function in ASH1 mRNA localization.
Zhang J, et al. (2011). Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
Lo Presti L, et al. (2011 Dec 20). Shaping fission yeast cells by rerouting actin-based transport on microtubules.
Bendezú FO, et al. (2011 Jan 1). Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.
Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.
Skau CT, et al. (2011 Jul 29). Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
Rossi G, et al. (2011 Mar 15). Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Bendezú FO, et al. (2012). Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles.
Taheri-Talesh N, et al. (2012). The functions of myosin II and myosin V homologs in tip growth and septation in Aspergillus nidulans.
Cortés JC, et al. (2012 Aug 20). Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.
Lo Presti L, et al. (2012 Dec). Myosin Vs organize actin cables in fission yeast.
Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Jourdain I, et al. (2012 Nov). Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton.
Zhang D, et al. (2012 Nov 6). Plasma membrane tethering of the cortical ER necessitates its finely reticulated architecture.
Vjestica A, et al. (2013). Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.
Bendezú FO, et al. (2013 Jan 7). Cdc42 explores the cell periphery for mate selection in fission yeast.
Cadou A, et al. (2013 Mar). The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Clayton JE, et al. (2014 Jan). Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.
Wang N, et al. (2015 Jan 15). The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.
Dudin O, et al. (2015 Mar 30). A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.
Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.
Wang N, et al. (2016 Apr). Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis.
Wei B, et al. (2016 Apr 15). Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.
Vjestica A, et al. (2016 Mar 9). Microscopy of Fission Yeast Sexual Lifecycle.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
4 genes with posterior transmembrane prediction > 50% |
||
FOG01842
EOG8WDBSN
sce:MYO1
Genes: 23
EOG8WDBSN
sce:MYO1
Genes: 23
SGD Description
Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
PomBase Description
myosin II heavy chain|myosin II heavy chain Myo3
AspGD Description
Ortholog(s) have role in asexual sporulation resulting in formation of a cellular spore, mitotic cytokinesis, nuclear migration during mitotic telophase, septin ring assembly
References
Watts FZ, et al. (1987 Nov). The yeast MYO1 gene encoding a myosin-like protein required for cell division.
Sweeney FP, et al. (1990 Dec 11). The MYO1 gene from Saccharomyces cerevisiae: its complete nucleotide sequence.
Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.
Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.
Taheri-Talesh N, et al. (2012). The functions of myosin II and myosin V homologs in tip growth and septation in Aspergillus nidulans.
Hill TW, et al. (2015 Feb). A mutation in the converter subdomain of Aspergillus nidulans MyoB blocks constriction of the actomyosin ring in cytokinesis.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG01843
EOG8WDBSN
sce:absent
Genes: 1
EOG8WDBSN
sce:absent
Genes: 1
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
