FOG01761
EOG8KD52G

sce:GAL1;GAL3

Genes: 28

SGD Description
Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication|Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication


PomBase Description
galactokinase Gal1


AspGD Description
Galactokinase with a predicted role in galactose catabolism; Leloir pathway enzyme


References

Arst HN Jr, et al. (1970). Molybdate metabolism in Aspergillus nidulans. II. Mutations affecting phosphatase activity or galactose utilization.

Roberts CF, et al. (1970 Feb 24). Enzyme lesions in galactose non-utilising mutants of Aspergillus nidulans.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Schlesinger DH, et al. (1977 Nov 1). The NH2-terminal sequences of galactokinase from Escherichia coli and Saccharomyces cerevisiae.

Citron BA, et al. (1984 Apr). Sequence of the Saccharomyces GAL region and its transcription in vivo.

Johnston M, et al. (1984 Aug). Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.

Bajwa W, et al. (1988 Aug). Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.

Webster TD, et al. (1988 Aug 25). Nucleotide sequence of the galactose gene cluster of Kluyveromyces lactis.

Meyer J, et al. (1991 Nov). Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Fekete E, et al. (2004 Jan). The alternative D-galactose degrading pathway of Aspergillus nidulans proceeds via L-sorbose.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Dalrymple SA, et al. (2011 Aug 1). Preliminary X-ray crystallographic studies of UDP-glucose-4-epimerase from Aspergillus nidulans.

Christensen U, et al. (2011 Oct). Unique regulatory mechanism for D-galactose utilization in Aspergillus nidulans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01762


sce:absent

Genes: 0

Protein description
reserved for ohnolog GAL1/GAL3


Parent
ohnolog:FOG01761

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%