FOG01703
EOG8VQ86H

sce:GRX4;GRX3

Genes: 34

SGD Description
Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication|Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication


PomBase Description
monothiol glutaredoxin Grx4


AspGD Description
Ortholog(s) have RNA polymerase II activating transcription factor binding, glutathione disulfide oxidoreductase activity


References

Kumánovics A, et al. (2008 Apr 18). Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

Gibson LM, et al. (2008 Sep). Structure of the thioredoxin-like domain of yeast glutaredoxin 3.

Li H, et al. (2009 Oct 13). The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01704
EOG8VQ86H

sce:GRX5

Genes: 31

SGD Description
Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p


PomBase Description
monothiol glutaredoxin Grx5


AspGD Description
Ortholog(s) have glutathione disulfide oxidoreductase activity, role in cellular response to oxidative stress, response to osmotic stress and mitochondrial matrix localization


References

Nakai K, et al. (1999 Jan). PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization.

Rodríguez-Manzaneque MT, et al. (2002 Apr). Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes.

Tamarit J, et al. (2003 Jul 11). Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin.

Kim HG, et al. (2005 Aug 31). The fission yeast gene encoding monothiol glutaredoxin 5 is regulated by nitrosative and osmotic stresses.

Chung WH, et al. (2005 May 6). Localization and function of three monothiol glutaredoxins in Schizosaccharomyces pombe.

Kim KD, et al. (2010 Feb 12). Monothiol glutaredoxin Grx5 interacts with Fe-S scaffold proteins Isa1 and Isa2 and supports Fe-S assembly and DNA integrity in mitochondria of fission yeast.

Uzarska MA, et al. (2013 Jun). The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Melber A, et al. (2016 Aug 17). Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients.

Uzarska MA, et al. (2016 Aug 17). Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%