FOG01697
EOG83J9MN

sce:ECM38

Genes: 34

SGD Description
Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation


PomBase Description
gamma-glutamyltranspeptidase Ggt1|gamma-glutamyltranspeptidase Ggt2


AspGD Description
Ortholog(s) have gamma-glutamyltransferase activity, role in cell redox homeostasis, glutathione metabolic process and endoplasmic reticulum, extracellular region localization


References

Penninckx M, et al. (1980 Feb). Glutathione metabolism in relation to the amino-acid permeation systems of the yeast Saccharomyces cerevisiae. Occurrence of gamma-glutamyltranspeptidase: its regulation and the effects of permeation mutations on the enzyme cellular level.

Payne GM, et al. (1984 Feb 15). gamma-Glutamyltransferase is not involved in the bulk uptake of amino acids, peptides or gamma-glutamyl-amino acids in yeast (Saccharomyces cerevisiae).

Jaspers CJ, et al. (1984 Jan). Glutathione metabolism in yeast Saccharomyces cerevisiae. Evidence that gamma-glutamyltranspeptidase is a vacuolar enzyme.

Elskens MT, et al. (1991 Mar). Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiae.

Mehdi K, et al. (1997 Jun). An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae.

Lussier M, et al. (1997 Oct). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.

Mehdi K, et al. (2001 Nov 1). gamma-Glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathione.

Springael JY, et al. (2003 Apr 15). Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3.

Kumar C, et al. (2003 Jul 30). Investigations into the polymorphisms at the ECM38 locus of two widely used Saccharomyces cerevisiae S288C strains, YPH499 and BY4742.

Park HJ, et al. (2004 Jan). Characterization and regulation of the gamma-glutamyl transpeptidase gene from the fission yeast Schizosaccharomyces pombe.

Kim HG, et al. (2005 Feb). The Schizosaccharomyces pombe gene encoding gamma-glutamyl transpeptidase I is regulated by non-fermentable carbon sources and nitrogen starvation.

Park HJ, et al. (2005 Mar). Characterization of a second gene encoding gamma-glutamyl transpeptidase from Schizosaccharomyces pombe.

Kang HJ, et al. (2005 Sep 30). The gene encoding gamma-glutamyl transpeptidase II in the fission yeast is regulated by oxidative and metabolic stress.

Song SH, et al. (2008 Feb). Nitrogen depletion causes up-regulation of glutathione content and gamma-glutamyltranspeptidase in Schizosaccharomyces pombe.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 14 genes with posterior transmembrane prediction > 50%