FOG01678
EOG8WM38K
ADE3.2
sce:absent

Genes: 32

Protein description
Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase


Features
[c]


SGD Description
Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase


PomBase Description
C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1


AspGD Description
Dihydrofolate reductase; methenyltetrahydrofolate cyclohydrolase


Suggested Analysis
Check consistency of [m] and [c] orthologs


References

Wahls WP, et al. (1993 Nov 15). Single-stranded DNA binding activity of C1-tetrahydrofolate synthase enzymes.

Freitas JS, et al. (2011 Sep). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01679
EOG8WM38K
MIS1
sce:MIS1

Genes: 26

Protein description
Mitochondrial trifunctional enzyme C1-tetrahydrofolate synthase


Features
[m]


Parent
paralog:FOG01678


References

Shannon KW, et al. (1986 Sep 15). Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae.

Shannon KW, et al. (1988 Jun 5). Isolation and characterization of the Saccharomyces cerevisiae MIS1 gene encoding mitochondrial C1-tetrahydrofolate synthase.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01680
EOG8WM38K
ADE3.3
sce:absent

Genes: 1

Protein description
Uncharacterized mitochondrial trifunctional enzyme C1-tetrahydrofolate synthase


Features
[m]


Parent
paralog:FOG01678

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01681
EOG8WM38K
ADE3
sce:ADE3

Genes: 1

Protein description
Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase


Features
[c]


Parent
ohnolog:FOG01678


SGD Description
Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine


References

Staben C, et al. (1986 Apr 5). Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.

Barlowe CK, et al. (1989 Mar 7). Site-directed mutagenesis of yeast C1-tetrahydrofolate synthase: analysis of an overlapping active site in a multifunctional enzyme.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01682
EOG8WM38K
ADH3.4
sce:absent

Genes: 1

Protein description
Mitochondrial C1-tetrahydrofolate synthase; convergent evolution with FOG01679; derived from cytoplasmic enzyme


Features
[m]


Parent
paralog:FOG01678


PomBase Description
C-1-tetrahydrofolatesynthase/methylenetetrahydrof olatedehydrogenase/methylenetetrahydrofolatecyclohydrolase/ formyltetrahydrofolatesynthetase (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%