FOG01619
EOG81RNB6
EOG870S00
EOG8C2FRX

sce:PHO3;PHO5;PHO11;PHO12;DIA3

Genes: 54

SGD Description
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin|Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2|One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication|One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication|Protein of unknown function; involved in invasive and pseudohyphal growth


PomBase Description
acid phosphatase (predicted)|acid phosphatase Pho1|thiamine-repressible acid phosphatase Pho4


AspGD Description
Ortholog(s) have thiamine phosphate phosphatase activity|Phytase (myo-inositol-hexakisphosphate phosphohydrolase); narrow pH optimum at around 2.5, very little activity at pH 5.0


References

Arima K, et al. (1983 Mar 25). The nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide.

Bajwa W, et al. (1984 Oct 25). Structural analysis of the two tandemly repeated acid phosphatase genes in yeast.

Maundrell K, et al. (1985). Cloning and characterization of two genes restoring acid phosphatase activity in pho1- mutants of Schizosaccharomyces pombe.

Coddington A, et al. (1986). Acid phosphatase deficient mutants of Schizosaccharomyces pombe are defective in tyrosine uptake.

Elliott S, et al. (1986 Feb 25). Isolation and characterization of the structural gene for secreted acid phosphatase from Schizosaccharomyces pombe.

Schweingruber AM, et al. (1986 Jul 1). Glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe.

Tait-Kamradt AG, et al. (1986 Jun). Reciprocal regulation of the tandemly duplicated PHO5/PHO3 gene cluster within the acid phosphatase multigene family of Saccharomyces cerevisiae.

Schwaninger R, et al. (1990 May). Effects of seven different mutations in the pho1 gene on enzymatic activity, glycosylation and secretion of acid phosphatase in Schizosaccharomyces pombe.

Yang JW, et al. (1990 Oct). The structural gene coding for thiamin-repressible acid phosphatase in Schizosaccharomyces pombe.

Schweingruber AM, et al. (1991 Apr). Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport.

Schweingruber ME, et al. (1992 Oct). Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate.

Althoff SM, et al. (1994 Dec). The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe.

Fankhauser H, et al. (1995 Nov 24). Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth.

Jannatipour M, et al. (1998 Dec 8). Calnexin and BiP interact with acid phosphatase independently of glucose trimming and reglucosylation in Schizosaccharomyces pombe.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Decottignies A, et al. (2003 Mar). Schizosaccharomyces pombe essential genes: a pilot study.

Kennedy EJ, et al. (2005 Nov). Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae.

Monahan BJ, et al. (2008 Aug). Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Hogan CJ, et al. (2010 Feb). Fission yeast Iec1-ino80-mediated nucleosome eviction regulates nucleotide and phosphate metabolism.

Ma Y, et al. (2011). Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Estravís M, et al. (2011 Dec). Cdc42 regulates multiple membrane traffic events in fission yeast.

Henry TC, et al. (2011 Feb). Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Fontebasso Y, et al. (2013 Dec). The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.

Lee NN, et al. (2013 Nov 21). Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Shah S, et al. (2014 Feb 1). lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Estill M, et al. (2015 May). Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01620
EOG8C2FRX

sce:absent

Genes: 12

AspGD Description
Has domain(s) with predicted acid phosphatase activity|Has domain(s) with predicted acid phosphatase activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01621
EOG870S00

sce:absent

Genes: 4

AspGD Description
Phytase (myo-inositol-hexakisphosphate phosphohydrolase), extracellular enzyme that hydrolyzes myo-inositol hexakisphosphate (phytate) to myo-inositol and inorganic phosphate; inhibited by vanadate anions; pH optima at 2.5 and 5.5

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01622
EOG8C2FRX

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01623
EOG8C2FRX

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01624
EOG8C2FRX

sce:absent

Genes: 10

AspGD Description
Phytase; expression repressed by tunicamycin and DTT

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%