FOG01615
EOG8ZCRQF

sce:RIB4

Genes: 30

SGD Description
Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase


PomBase Description
6,7-dimethyl-8-ribityllumazine synthase


AspGD Description
Ortholog(s) have 6,7-dimethyl-8-ribityllumazine synthase activity, riboflavin binding activity, role in riboflavin biosynthetic process and mitochondrial intermembrane space, nucleus localization


References

Cove DJ, et al. (1979 Aug). Genetic studies of nitrate assimilation in Aspergillus nidulans.

García-Ramírez JJ, et al. (1995 Oct 6). The Saccharomyces cerevisiae RIB4 gene codes for 6,7-dimethyl-8-ribityllumazine synthase involved in riboflavin biosynthesis. Molecular characterization of the gene and purification of the encoded protein.

Mörtl S, et al. (1996 Dec 27). Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Meining W, et al. (2000 May 26). The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Shankar M, et al. (2013 Aug). Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%