FOG01608
EOG8WDBTP

sce:RIB2

Genes: 33

SGD Description
Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication


PomBase Description
tRNA pseudouridine synthase (predicted)


AspGD Description
Ortholog(s) have pseudouridine synthase activity, role in tRNA pseudouridine synthesis and cytosol, mitochondrion, nucleus localization


References

Bacher A, et al. (1969 Dec 30). Biosynthesis of riboflavin. Mutants accumulating 6-hydroxy-2,4,5-triaminopyrimidine.

Oltmanns O, et al. (1972 Jun). Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 .

Bañuelos M, et al. (1977 Sep 25). Activation by phosphate of yeast phosphofructokinase.

Behm-Ansmant I, et al. (2004 Dec 17). Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01609
EOG8WDBTP

sce:PUS9

Genes: 1

SGD Description
Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication


References

Behm-Ansmant I, et al. (2004 Dec 17). Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01610
EOG8WDBTP
EOG8WDBV0

sce:PUS6

Genes: 22

SGD Description
tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability


References

Ansmant I, et al. (2001 Sep 14). Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%