FOG01571
EOG8R22DB

sce:CDC8

Genes: 34

SGD Description
Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p


PomBase Description
thymidylate kinase Tmp1


AspGD Description
Uridylate kinase


References

Birkenmeyer LG, et al. (1984 Apr). Saccharomyces cerevisiae CDC8 gene and its product.

Jong AY, et al. (1984 Sep 10). The CDC8 gene of yeast encodes thymidylate kinase.

Abaigar LT, et al. (1992 Sep 24). Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene.

Lavie A, et al. (1997 Aug). Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.

Lavie A, et al. (1998 Mar 17). Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%