FOG01550
EOG8HDR96

sce:IMD1;IMD2;IMD3;IMD4

Genes: 37

SGD Description
|Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication|Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication|Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication


PomBase Description
IMP dehydrogenase Gua1


AspGD Description
Inosine-5?-monophosphate dehydrogenase


References

Hyle JW, et al. (2003 Aug 1). Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast.

McPhillips CC, et al. (2004 Aug 17). Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo.

Zhang Z, et al. (2005). Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.

Köhler GA, et al. (2005 Mar 25). The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase.

Jenks MH, et al. (2005 Nov). Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG01551
EOG8HDR96

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%