FOG01528
EOG8XWDH3

sce:HPT1

Genes: 21

SGD Description
Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome


References

Schmidt R, et al. (1979 Jan 15). Purification and characterization of the hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae.

Nussbaum RL, et al. (1981 Aug 4). Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae.

Ali LZ, et al. (1982 Feb 10). Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast.

Woods RA, et al. (1984 Oct). Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.

Guetsova ML, et al. (1997 Oct). The isolation and characterization of Saccharomyces cerevisiae mutants that constitutively express purine biosynthetic genes.

Escobar-Henriques M, et al. (2001 Jan 12). Transcriptional regulation of the yeast gmp synthesis pathway by its end products.

Breton A, et al. (2008 Feb). Lethal accumulation of guanylic nucleotides in Saccharomyces cerevisiae HPT1-deregulated mutants.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG01529
EOG8XWDH3

sce:XPT1

Genes: 28

SGD Description
Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine


PomBase Description
xanthine phosphoribosyltransferase (predicted)


AspGD Description
Hypoxanthine phosphoribosyltransferase with a role in the salvage pathways for nucleotides


References

Housset P, et al. (1977 Feb 15). Study of the role of puring phosphoribosyltransferases in the uptake of adenine and guanine by Schizosaccharomyces pombe cells.

Nagy M, et al. (1977 Jul 1). Purification and comparative study of adenine and guanine phosphoribosyltransferases from Schizosaccharomyces pombe.

Guetsova ML, et al. (1999 May). Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Borlot F, et al. (2013 Aug). A novel mutation in HPRT1 gene causing variant form of Lesch-Nyhan disease.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%