FOG01510
EOG800011

sce:ADE13

Genes: 33

SGD Description
Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency


PomBase Description
adenylosuccinate lyase Ade8


AspGD Description
5?-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase


References

Kohli J, et al. (1977 Nov). Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Strauss A, et al. (1979 Jun). Allelism of methionine-sensitive mutants of Schizosaccharomyces pombe to loci involved in adenine biosynthesis.

Ishiguro J, et al. (1989 Jan). An abnormal cell division cycle in an AIR carboxylase-deficient mutant of the fission yeast Schizosaccharomyces pombe.

Speiser DM, et al. (1992 Dec). Purine biosynthetic genes are required for cadmium tolerance in Schizosaccharomyces pombe.

Schweingruber ME, et al. (1992 Oct). Regulation of pho1-encoded acid phosphatase of Schizosaccharomyces pombe by adenine and phosphate.

Juang RH, et al. (1993 Aug 1). Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro.

Benko Z, et al. (1997 Jun). Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle.

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 23 genes with posterior transmembrane prediction > 50%