FOG01499
EOG8547GG

sce:NIT1

Genes: 14

SGD Description
Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene


AspGD Description
Putative benzonitrilase|Putative benzonitrilase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01500
EOG8547GG

sce:absent

Genes: 2

SGD Description
Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene


AspGD Description
Putative benzonitrilase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01501
EOG8866WD

sce:NIT2

Genes: 33

SGD Description
Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member


PomBase Description
bis(5'-adenosyl)-triphosphatase (predicted)


AspGD Description
Putative benzonitrilase


References

Pace HC, et al. (2000 Jul 27-Aug 10). Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.

Liu H, et al. (2013 Aug). Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2.

Peracchi A, et al. (2017 Apr 18). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01502
EOG8866WD

sce:NIT3

Genes: 35

SGD Description
Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member


PomBase Description
omega-amidase (predicted)


AspGD Description
Putative benzonitrilase


References

Pace HC, et al. (2000 Jul 27-Aug 10). Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.

Kumaran D, et al. (2003 Aug 1). Crystal structure of a putative CN hydrolase from yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Peracchi A, et al. (2017 Apr 18). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%