FOG01395
EOG8M907V

sce:SPE1

Genes: 32

SGD Description
Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation


PomBase Description
ornithine decarboxylase Spe1 (predicted)


AspGD Description
Ortholog(s) have ornithine decarboxylase activity, role in DNA biosynthetic process, nuclear division, putrescine biosynthetic process, spermidine biosynthetic process, spore germination and cytosol, nucleus localization


References

Tyagi AK, et al. (1981 Dec 10). Ornithine decarboxylase from Saccharomyces cerevisiae. Purification, properties, and regulation of activity.

Tabor CW, et al. (1982 Dec). The biochemistry, genetics, and regulation of polyamine biosynthesis in Saccharomyces cerevisiae.

Fonzi WA, et al. (1987 Jul 25). The gene and the primary structure of ornithine decarboxylase from Saccharomyces cerevisiae.

Fonzi WA, et al. (1989 Aug 15). Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase.

López MC, et al. (1997 Aug). The ornithine decarboxylase gene from Candida albicans. Sequence analysis and expression during dimorphism.

McNemar MD, et al. (1997 Nov). Isolation and sequence of the gene encoding ornithine decarboxylase, SPE1, from Candida albicans by complementation of a spe1 delta strain of Saccharomyces cerevisiae.

Palanimurugan R, et al. (2004 Dec 8). Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%