FOG01345
EOG8P2NH5

sce:BNA4

Genes: 32

SGD Description
Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease


AspGD Description
Ortholog(s) have kynurenine 3-monooxygenase activity


References

Panozzo C, et al. (2002 Apr 24). Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Giorgini F, et al. (2005 May). A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%

FOG01346
EOG8P2NH5

sce:absent

Genes: 2

AspGD Description
Putative kynurenine3-hydroxylase|Has domain(s) with predicted FAD binding, oxidoreductase activity and role in metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%