FOG01296
EOG83BK50
SHM1
sce:SHM1

Genes: 30

Protein description
Mitochondrial serine hydroxymethyltransferase


Features
[m]


SGD Description
Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine


PomBase Description
serine hydroxymethyltransferase Shm2 (predicted)


AspGD Description
Glycine hydroxymethyltransferase/serine hydroxymethyltransferase


References

McNeil JB, et al. (1994 Mar 25). Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine.

Schlüpen C, et al. (2003 Jan 15). Disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine in Ashbya gossypii.

Calvert ME, et al. (2008 Feb). Phosphorylation by casein kinase 2 regulates Nap1 localization and function.

Roberts-Galbraith RH, et al. (2010 Jul 9). Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Drogat J, et al. (2012 Nov 29). Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Halim A, et al. (2015 Dec 22). Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG01297
EOG83BK50
SHM2
sce:SHM2

Genes: 33

Protein description
Cytosolic serine hydroxymethyltransferase


Features
[c]


Parent
paralog:FOG01296


SGD Description
Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis


PomBase Description
serine hydroxymethyltransferase Shm1 (predicted)


AspGD Description
Glycine hydroxymethyltransferase/serine hydroxymethyltransferase


Suggested Analysis
Find origin of duplication


References

McNeil JB, et al. (1994 Mar 25). Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine.

Norbeck J, et al. (1997 Dec). Two-dimensional electrophoretic separation of yeast proteins using a non-linear wide range (pH 3-10) immobilized pH gradient in the first dimension; reproducibility and evidence for isoelectric focusing of alkaline (pI > 7) proteins.

McNeil JB, et al. (2000 Jan 30). Glycine metabolism in Candida albicans: characterization of the serine hydroxymethyltransferase (SHM1, SHM2) and threonine aldolase (GLY1) genes.

Schlüpen C, et al. (2003 Jan 15). Disruption of the SHM2 gene, encoding one of two serine hydroxymethyltransferase isoenzymes, reduces the flux from glycine to serine in Ashbya gossypii.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Sato I, et al. (2009 Mar 20). The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 19 genes with posterior transmembrane prediction > 50%