FOG01284
EOG89KD66
ILV1
sce:ILV1

Genes: 36

Protein description
Threonine deaminase


Features
[m]


SGD Description
Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation


PomBase Description
threonine ammonia-lyase Tda1


AspGD Description
Threonine dehydratase


Suggested Analysis
pic has misidentified start codon


References

McDonald RA, et al. (1973 Apr). Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: regulatory properties of threonine deaminase.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Ahmed SI, et al. (1976). Purification and properties of threonine deaminase from Saccharomyces cerevisiae.

Arst HN Jr, et al. (1977 Feb 28). Some genetical aspects of ornithine metabolism in Aspergillus nidulans.

Holmberg S, et al. (1988 Mar). Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%

FOG01285
EOG880GDB
EOG8F1VKW

sce:absent

Genes: 8

Protein description
Uncharacterized paralog

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01286
EOG880GDB
EOG8F1VKW

sce:CHA1;;SDL1

Genes: 19

Protein description
Catabolic L-serine (L-threonine) deaminase


SGD Description
Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine||


AspGD Description
L-serine dehydratase


References

Bornaes C, et al. (1992 Jul). Serine and threonine catabolism in Saccharomyces cerevisiae: the CHA1 polypeptide is homologous with other serine and threonine dehydratases.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG01287
EOG863XW2

sce:SRY1

Genes: 9

SGD Description
3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity


PomBase Description
serine racemase Sry1


AspGD Description
Ortholog(s) have ATP binding, D-serine ammonia-lyase activity, L-serine ammonia-lyase activity, magnesium ion binding, pyridoxal phosphate binding, serine racemase activity and role in D-serine metabolic process, L-serine metabolic process


Suggested Analysis
Check if sce copy is a xenolog


References

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Yamauchi T, et al. (2009 Apr). Serine racemase with catalytically active lysinoalanyl residue.

Goto M, et al. (2009 Sep 18). Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Harty M, et al. (2014 Jan 1). Inhibition of serine and proline racemases by substrate-product analogues.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%