FOG01282
EOG815DX2

sce:HOM6

Genes: 35

SGD Description
Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions


PomBase Description
homoserine dehydrogenase (predicted)


AspGD Description
Homoserine dehydrogenase


References

Yumoto N, et al. (1991 Mar). Rapid purification and characterization of homoserine dehydrogenase from Saccharomyces cerevisiae.

Thomas D, et al. (1993 Jun 1). Evolutionary relationships between yeast and bacterial homoserine dehydrogenases.

DeLaBarre B, et al. (2000 Mar). Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.

Jacques SL, et al. (2003 Oct). Enzyme-assisted suicide: molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase.

Ejim L, et al. (2004 Jul 15). New phenolic inhibitors of yeast homoserine dehydrogenase.

Kim Y, et al. (2007 Sep). Proteome map of Aspergillus nidulans during osmoadaptation.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%