FOG01279
EOG80001M

sce:CAR2

Genes: 35

SGD Description
L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant


PomBase Description
ornithine transaminase Car2


AspGD Description
Ornithine transaminase|Ornithine transaminase


References

Piotrowska M, et al. (1969 Feb). Mutants of the arginine-proline pathway in Aspergillus nidulans.

Cybis J, et al. (1972). Genetic control of the arginine pathways in Aspergillus nidulans. Common regulation of anabolism and catabolism.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Bartnik E, et al. (1973 Oct 16). Ammonium and glucose repression of the arginine catabolic enzymes in Aspergillus nidulans.

Wegleński P, et al. (1974). [Genetic regulation of arginine metabolism in fungi (author's transl)].

Arst HN Jr, et al. (1977 Feb 28). Some genetical aspects of ornithine metabolism in Aspergillus nidulans.

Bartnik E, et al. (1978). Catabolite repression in Aspergillus nidulans; the role of glutamine synthetase.

Degols G, et al. (1987 Jun 1). Molecular characterization of transposable-element-associated mutations that lead to constitutive L-ornithine aminotransferase expression in Saccharomyces cerevisiae.

Degols G, et al. (1987 Nov 16). Functional analysis of the regulatory region adjacent to the cargB gene of Saccharomyces cerevisiae. Nucleotide sequence, gene fusion experiments and cis-dominant regulatory mutation analysis.

Dzikowska A, et al. (1999 Mar). Cloning, characterisation and regulation of the ornithine transaminase (otaA) gene of Aspergillus nidulans.

Dzikowska A, et al. (2003 Mar). Specific induction and carbon/nitrogen repression of arginine catabolism gene of Aspergillus nidulans--functional in vivo analysis of the otaA promoter.

Olszewska A, et al. (2007 Dec). Arginine catabolism in Aspergillus nidulans is regulated by the rrmA gene coding for the RNA-binding protein.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Macios M, et al. (2012 Mar). The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source.

Krol K, et al. (2013 Sep). RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress.

Romagnoli G, et al. (2014 Jul). An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme.

Dzikowska A, et al. (2015 Dec 1). KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%