FOG01125
EOG8PC88M

sce:LYS1

Genes: 35

SGD Description
Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity


PomBase Description
saccharopine dehydrogenase Lys3


AspGD Description
Saccharopine dehydrogenase


References

Käfer E, et al. (1965 Jul). Origins of translocations in Aspergillus nidulans.

Saunders PP, et al. (1966 Jul 25). Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.

Fujioka M, et al. (1970 Sep). A kinetic study of saccharopine dehydrogenase reaction.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Ogawa H, et al. (1978 May 25). Purification and characterization of saccharopine dehydrogenase from baker's yeast.

Ogawa H, et al. (1979 Aug 10). Chemical modification of the active site sulfhydryl group of saccharopine dehydrogenase (L-lysine-forming).

Ogawa H, et al. (1980 Aug 10). The reaction of pyridoxal 5'-phosphate with an essential lysine residue of saccharopine dehydrogenase (L-lysine-forming).

Fujioka M, et al. (1980 Feb 10). The inactivation of saccharopine dehydrogenase (L-lysine-forming) by diethyl pyrocarbonate.

Ogawa H, et al. (1980 May 29). Amino acid sequence of a peptide containing an essential cysteine residue of yeast saccharopine dehydrogenase (L-lysine-forming).

Ramos F, et al. (1988 Jan 15). Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14.

Xuan JW, et al. (1990 Sep). Overlapping reading frames at the LYS5 locus in the yeast Yarrowia lipolytica.

Tang CM, et al. (1994 Dec). Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis.

Busch S, et al. (2003 Jan). Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans.

Teves F, et al. (2009 Dec). Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%