FOG00988
EOG84MW79

sce:ILV2

Genes: 34

SGD Description
Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control


PomBase Description
acetolactate synthase catalytic subunit


AspGD Description
Acetolactate synthase|Acetolactate synthase


References

McDonald RA, et al. (1973 Apr). Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: properties of acetohydroxy acid synthetase.

McDonald RA, et al. (1974 Jan). Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: regulation of the enzymes involved in isoleucine, valine, and leucine synthesis.

Falco SC, et al. (1985 Jun 11). Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase.

Bekkaoui F, et al. (1993 Dec). Isolation and structure of an acetolactate synthase gene from Schizosaccharomyces pombe and complementation of the ilv2 mutation in Saccharomyces cerevisiae.

Pang SS, et al. (1999 Apr 20). Expression, purification, characterization, and reconstitution of the large and small subunits of yeast acetohydroxyacid synthase.

Pang SS, et al. (2002 Mar 22). Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors.

Pang SS, et al. (2003 Feb 28). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase.

Shimizu M, et al. (2010 Mar). Mechanism of de novo branched-chain amino acid synthesis as an alternative electron sink in hypoxic Aspergillus nidulans cells.

Anderson HE, et al. (2010 Oct 18). Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00989
EOG84MW79

sce:absent

Genes: 1

Parent
paralog:FOG00988


AspGD Description
Acetolactate synthase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%