FOG00957
EOG81ZCS9
EOG8D255F
ICL1
sce:ICL1
Genes: 32
EOG81ZCS9
EOG8D255F
ICL1
sce:ICL1
Genes: 32
Protein description
Isocitrate lyase
SGD Description
Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
PomBase Description
isocitrate lyase (predicted)
AspGD Description
Putative isocitrate lyase
References
Armitt S, et al. (1970 Apr 16). The role of isocitrate lyase in Aspergillus Nidulans.
McFadden BA, et al. (1972 Jan). Production of pyruvate and succinate by action of isocitrate lyase on -methylisocitrate.
Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.
Armitt S, et al. (1976 Feb). Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans.
Payton M, et al. (1976 May). Agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of Aspergillus nidulans.
McCullough W, et al. (1980 Sep). Genetic regulation of isocitrate lyase activity in Aspergillus nidulans.
Ballance DJ, et al. (1986 Feb). Gene cloning in Aspergillus nidulans: isolation of the isocitrate lyase gene (acuD).
Hynes MJ, et al. (1986 Sep). The amdS gene of Aspergillus nidulans: control by multiple regulatory signals.
Lopez-Boado YS, et al. (1988 Mar). Purification of isocitrate lyase from Saccharomyces cerevisiae.
López-Boado YS, et al. (1988 Sep). Glucose-stimulated phosphorylation of yeast isocitrate lyase in vivo.
Gainey LD, et al. (1992 Jan). Characterization of the glyoxysomal isocitrate lyase genes of Aspergillus nidulans (acuD) and Neurospora crassa (acu-3).
Fernández E, et al. (1992 Mar 15). The ICL1 gene from Saccharomyces cerevisiae.
McCullough W, et al. (1993 Mar). Properties of genes involved in the control of isocitrate lyase production in Aspergillus nidulans.
Schöler A, et al. (1993 May-Jun). Structure and regulation of the isocitrate lyase gene ICL1 from the yeast Saccharomyces cerevisiae.
Barth G, et al. (1993 Nov). Cloning of the isocitrate lyase gene (ICL1) from Yarrowia lipolytica and characterization of the deduced protein.
De Lucas JR, et al. (1994). Glucose-induced inactivation of isocitrate lyase in Aspergillus nidulans.
Bowyer P, et al. (1994 Feb). Regulation of the expression of the isocitrate lyase gene (acuD) of Aspergillus nidulans.
De Lucas JR, et al. (1994 Jun 15). Analysis of the regulation of the Aspergillus nidulans acuD gene, encoding isocitrate lyase, by construction of a hybrid promoter.
Kawasaki L, et al. (1995 Mar). Aspergillus nidulans mutants affected in acetate metabolism isolated as lipid nonutilizers.
Ordiz I, et al. (1996 Apr 29). Glucose-induced inactivation of isocitrate lyase in Saccharomyces cerevisiae is mediated by the cAMP-dependent protein kinase catalytic subunits Tpk1 and Tpk2.
Heinisch JJ, et al. (1996 Oct). Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae.
Taylor KM, et al. (1996 Oct 1). Localization and targeting of isocitrate lyases in Saccharomyces cerevisiae.
Langridge SJ, et al. (1997 Jul 1). Isocitrate lyase from Aspergillus nidulans: crystallization and X-ray analysis of a glyoxylate cycle enzyme.
Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.
Chaves RS, et al. (1997 Oct 1). Isocitrate lyase localisation in Saccharomyces cerevisiae cells.
Todd RB, et al. (1998 Apr 1). FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences.
Stemple CJ, et al. (1998 Dec). The facC gene of Aspergillus nidulans encodes an acetate-inducible carnitine acetyltransferase.
Ordiz I, et al. (1998 Jan 15). A 27 kDa protein binds to a positive and a negative regulatory sequence in the promoter of the ICL1 gene from Saccharomyces cerevisiae.
Valenciano S, et al. (1998 Oct). Characterization of Aspergillus nidulans peroxisomes by immunoelectron microscopy.
Maeting I, et al. (1999 Feb 5). Isocitrate lyase of Ashbya gossypii--transcriptional regulation and peroxisomal localization.
Rahner A, et al. (1999 Oct). Deregulation of gluconeogenic structural genes by variants of the transcriptional activator Cat8p of the yeast Saccharomyces cerevisiae.
Britton K, et al. (2000 Apr 15). The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans.
Luttik MA, et al. (2000 Dec). The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.
Dessen P, et al. (2000 Feb 22). The PAUSE software for analysis of translational control over protein targeting: application to E. nidulans membrane proteins.
Amor C, et al. (2000 Jul-Aug). The catabolite inactivation of Aspergillus nidulans isocitrate lyase occurs by specific autophagy of peroxisomes.
Lorenz MC, et al. (2001 Jul 5). The glyoxylate cycle is required for fungal virulence.
Hynes MJ, et al. (2002 Jan). Regulation of the acuF gene, encoding phosphoenolpyruvate carboxykinase in the filamentous fungus Aspergillus nidulans.
Osherov N, et al. (2002 Nov). Identification of conidial-enriched transcripts in Aspergillus nidulans using suppression subtractive hybridization.
Sims AH, et al. (2004 Feb). Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans.
López ML, et al. (2004 Jan). Isocitrate lyase of the yeast Kluyveromyces lactis is subject to glucose repression but not to catabolite inactivation.
David H, et al. (2006). Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.
Mogensen J, et al. (2006 Aug). Transcription analysis using high-density micro-arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol.
Cánovas D, et al. (2006 Dec). Developmental regulation of the glyoxylate cycle in the human pathogen Penicillium marneffei.
Hynes MJ, et al. (2006 May). Regulatory genes controlling fatty acid catabolism and peroxisomal functions in the filamentous fungus Aspergillus nidulans.
Sarry JE, et al. (2007 Aug). Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae.
Belinchón MM, et al. (2007 Sep). Glucose controls multiple processes in Saccharomyces cerevisiae through diverse combinations of signaling pathways.
Hynes MJ, et al. (2008 Mar). Genetic analysis of the role of peroxisomes in the utilization of acetate and fatty acids in Aspergillus nidulans.
Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.
Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.
Brown CR, et al. (2010 Jul 23). The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway.
Lee YJ, et al. (2011 Feb). TCA cycle-independent acetate metabolism via the glyoxylate cycle in Saccharomyces cerevisiae.
Chen Y, et al. (2012). Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae.
Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Orlandi I, et al. (2013). Ethanol and acetate acting as carbon/energy sources negatively affect yeast chronological aging.
Casatta N, et al. (2013 Mar). Lack of Sir2 increases acetate consumption and decreases extracellular pro-aging factors.
Giardina BJ, et al. (2014). The endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Giardina BJ, et al. (2014 Feb 12). Glucose induces rapid changes in the secretome of Saccharomyces cerevisiae.
Flipphi M, et al. (2014 Jul). The Aspergillus nidulans acuL gene encodes a mitochondrial carrier required for the utilization of carbon sources that are metabolized via the TCA cycle.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
10 genes with posterior transmembrane prediction > 50% |
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FOG00958
EOG81ZCS9
ICL2
sce:ICL2
Genes: 16
EOG81ZCS9
ICL2
sce:ICL2
Genes: 16
Protein description
Methylisocitrate lyase, may play a role in threonine degradation
Parent
paralog:FOG00957
SGD Description
2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
AspGD Description
2-methylisocitrate lyase
References
Uchiyama H, et al. (1982 Jul). Subcellular localization of the methylcitric-acid-cycle enzymes in propionate metabolism of Yarrowia lipolytica.
Heinisch JJ, et al. (1996 Oct). Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae.
Luttik MA, et al. (2000 Dec). The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.
Brock M, et al. (2001 Jun). 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes.
Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.
Brock M, et al. (2005 Sep). Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation.
Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.
Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG00959
sce:absent
Genes: 2
sce:absent
Genes: 2
Parent
paralog:FOG00958
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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 |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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