FOG00908
EOG81JWVD
XYL2
sce:XYL2

Genes: 36

Protein description
Xylitol dehydrogenase


SGD Description
Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect


PomBase Description
hexitol dehydrogenase (predicted)


AspGD Description
D-xylulose reductase (xylitol dehydrogenase); L-iditol 2-dehydrogenase; XlnR regulated gene; upregulated on l-arabinose, not on d-galactose, galactitol or d-sorbitol


References

Kötter P, et al. (1990 Dec). Isolation and characterization of the Pichia stipitis xylitol dehydrogenase gene, XYL2, and construction of a xylose-utilizing Saccharomyces cerevisiae transformant.

Persson B, et al. (1993 Jun 7). Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types.

Wagner P, et al. (1994 Dec). Isolation and characterization of two monoclonal antibodies raised against tms1 protein of fission yeast.

Richard P, et al. (1999 Aug 20). Evidence that the gene YLR070c of Saccharomyces cerevisiae encodes a xylitol dehydrogenase.

Shi NQ, et al. (2000 Spring). Characterization and complementation of a Pichia stipitis mutant unable to grow on D-xylose or L-arabinose.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Andersen MR, et al. (2008 Mar 18). A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Battaglia E, et al. (2011 Jul). Regulation of pentose utilisation by AraR, but not XlnR, differs in Aspergillus nidulans and Aspergillus niger.

Coradetti ST, et al. (2013 Aug). Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Kowalczyk JE, et al. (2015). Genetic Interaction of Aspergillus nidulans galR, xlnR and araR in Regulating D-Galactose and L-Arabinose Release and Catabolism Gene Expression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG00909
EOG81JWVD

sce:absent

Genes: 5

AspGD Description
D-xylulose reductase (xylitol dehydrogenase); sorbitol (glucitol) dehydrogenase (NAD+)|D-xylulose reductase (xylitol dehydrogenase); sorbitol (glucitol) dehydrogenase (NAD+)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00910
EOG81JWVD

sce:SOR1;SOR2

Genes: 2

Protein description
XYL2 unknown duplications


SGD Description
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose|Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism


References

Sarthy AV, et al. (1994 Mar 11). Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00911
EOG81JWVD

sce:absent

Genes: 10

Protein description
L-arabinitol 4-dehydrogenase.


AspGD Description
Putative L-arabitol dehydrogenase; D-sorbitol dehydrogenase; induced on l-arabinose but not on galactitol or d-galactose|D-sorbitol dehydrogenase|L-iditol 2-dehydrogenase (sorbitol dehydrogenase); exhibits galactitol-3-dehydrogenase activity; upregulated on d-galactose and galactitol, but not on l-arabinose or d-glucose


References

de Vries RP, et al. (1994 Oct 15). Characterization of an Aspergillus nidulans L-arabitol dehydrogenase mutant.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Gielkens M, et al. (1999 Mar). The abfB gene encoding the major alpha-L-arabinofuranosidase of Aspergillus nidulans: nucleotide sequence, regulation and construction of a disrupted strain.

Fekete E, et al. (2004 Jan). The alternative D-galactose degrading pathway of Aspergillus nidulans proceeds via L-sorbose.

Suzuki T, et al. (2005 Oct). Cloning and expression of NAD+-dependent L-arabinitol 4-dehydrogenase gene (ladA) of Aspergillus oryzae.

Andersen MR, et al. (2008 Mar 18). A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Kim B, et al. (2010 Jul). Cloning, characterization, and engineering of fungal L-arabinitol dehydrogenases.

Christensen U, et al. (2011 Oct). Unique regulatory mechanism for D-galactose utilization in Aspergillus nidulans.

Mojzita D, et al. (2012 Feb). Identification of the galactitol dehydrogenase, LadB, that is part of the oxido-reductive D-galactose catabolic pathway in Aspergillus niger.

Colabardini AC, et al. (2013). Functional characterization of Aspergillus nidulans ypkA, a homologue of the mammalian kinase SGK.

Kowalczyk JE, et al. (2015). Genetic Interaction of Aspergillus nidulans galR, xlnR and araR in Regulating D-Galactose and L-Arabinose Release and Catabolism Gene Expression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00912
EOG81JWVD

sce:absent

Genes: 14

Protein description
unknown function; monophyletic


AspGD Description
D-sorbitol dehydrogenase


References

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG00913
EOG81JWVD

sce:absent

Genes: 8

Protein description
unknown function; monophyletic


AspGD Description
L-iditol 2-dehydrogenase

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG00914
EOG81JWVD

sce:absent

Genes: 2

AspGD Description
Sorbitol dehydrogenase; enzyme of the last step of the oxido-reductive d-galactose pathway, oxidizes d-sorbitol to d-fructose; essential enzyme for growth on d-sorbitol as a sole carbon source; strongly upregulated on d-sorbitol|D-Xylulose reductase (xylitol dehydrogenase); sorbitol (glucitol) dehydrogenase (NAD+)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%