FOG00814
EOG8RJDJ7

sce:VMA5

Genes: 33

Protein description
VATPase.V1.C


SGD Description
Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits


PomBase Description
V-type ATPase V1 subunit C (predicted)


AspGD Description
Ortholog(s) have role in calcium ion transport into cytosol and cytosol, plasma membrane localization


References

Beltrán C, et al. (1992 Jan 15). Cloning and mutational analysis of the gene encoding subunit C of yeast vacuolar H(+)-ATPase.

Ho MN, et al. (1993 Jan 5). Isolation of vacuolar membrane H(+)-ATPase-deficient yeast mutants; the VMA5 and VMA4 genes are essential for assembly and activity of the vacuolar H(+)-ATPase.

Parra KJ, et al. (2000 Jul 14). The H subunit (Vma13p) of the yeast V-ATPase inhibits the ATPase activity of cytosolic V1 complexes.

Curtis KK, et al. (2002 Mar 15). Mutational analysis of the subunit C (Vma5p) of the yeast vacuolar H+-ATPase.

Drory O, et al. (2004 Dec). Crystal structure of yeast V-ATPase subunit C reveals its stator function.

Gachet Y, et al. (2005 Dec 1). btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

Jones RP, et al. (2005 Mar 15). Defined sites of interaction between subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the stator structure of the vacuolar H+-ATPase.

Armbrüster A, et al. (2005 Mar 28). Evidence for major structural changes in subunit C of the vacuolar ATPase due to nucleotide binding.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%