FOG00812
EOG8CJSZD

sce:VMA1

Genes: 33

Protein description
VATPase.V1.A


SGD Description
Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner


PomBase Description
V-type ATPase V1 domain, subunit A


AspGD Description
Ortholog(s) have role in arginine homeostasis, cellular response to oxidative stress, endocytosis, histidine homeostasis, lysine homeostasis, methylamine metabolic process, pathogenesis, vacuolar acidification


References

Shih CK, et al. (1988 Aug). A dominant trifluoperazine resistance gene from Saccharomyces cerevisiae has homology with F0F1 ATP synthase and confers calcium-sensitive growth.

Hirata R, et al. (1990 Apr 25). Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae.

Kane PM, et al. (1990 Nov 2). Protein splicing converts the yeast TFP1 gene product to the 69-kD subunit of the vacuolar H(+)-adenosine triphosphatase.

Ronne H, et al. (1991 Oct). Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

Grivell LA, et al. (1992 Aug). Homing in on an endosymbiotic endonuclease.

Gimble FS, et al. (1992 May 28). Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae.

Hirata R, et al. (1992 Oct 15). Mutations at the putative junction sites of the yeast VMA1 protein, the catalytic subunit of the vacuolar membrane H(+)-ATPase, inhibit its processing by protein splicing.

Cooper AA, et al. (1993 Jun). Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision.

Verhasselt P, et al. (1995 Aug). New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae.

Duan X, et al. (1997 May 16). Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity.

Förster C, et al. (1999 Apr 2). Physiological consequence of disruption of the VMA1 gene in the riboflavin overproducer Ashbya gossypii.

Hu D, et al. (2000 Jan 28). Probing the structure of the PI-SceI-DNA complex by affinity cleavage and affinity photocross-linking.

Poland BW, et al. (2000 Jun 2). Structural insights into the protein splicing mechanism of PI-SceI.

Seol JH, et al. (2001 Apr). Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.

Mizutani R, et al. (2002 Mar 1). Protein-splicing reaction via a thiazolidine intermediate: crystal structure of the VMA1-derived endonuclease bearing the N and C-terminal propeptides.

Werner E, et al. (2002 Sep 15). High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%