FOG00800
EOG8FBGFN

sce:STF1

Genes: 1

Protein description
ATPase.regulation


SGD Description
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication


References

Matsubara H, et al. (1983 Jul). A stabilizing factor of yeast mitochondrial F1F0-ATPase-inhibitor complex: common amino acid sequence with yeast ATPase inhibitor and E. coli epsilon and bovine delta subunits.

Akashi A, et al. (1988 Oct). Molecular cloning and expression of a gene for a factor which stabilizes formation of inhibitor-mitochondrial ATPase complex from Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00801
EOG8FBGFN

sce:INH1

Genes: 24

Protein description
ATPase


SGD Description
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication


AspGD Description
Ortholog(s) have ATPase inhibitor activity, role in negative regulation of ATPase activity and mitochondrion localization


References

Matsubara H, et al. (1981 Oct). Amino acid sequence of an intrinsic inhibitor of mitochondrial ATPase from yeast.

Yoshida Y, et al. (1983 Jul). Partial amino terminal sequence of the precursor of mitochondrial ATPase inhibitor protein synthesized with mRNA partially purified by gel permeation chromatography.

Ichikawa N, et al. (1990 Apr 15). Activation of ATP hydrolysis by an uncoupler in mutant mitochondria lacking an intrinsic ATPase inhibitor in yeast.

Verhasselt P, et al. (1995 Aug). New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae.

Ichikawa N, et al. (2000 Jan). Requirement for lysine-19 of the yeast mitochondrial ATPase inhibitor for the stability of the inactivated inhibitor-F1Fo complex at higher pH.

Savoldi M, et al. (2008 Oct). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans Apoptosis-Inducing Factor (AIF)-like mitochondrial oxidoreductase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00802
EOG8FBGFN

sce:absent

Genes: 3

PomBase Description
mitochondrial proton-transporting ATP synthase inhibitor (predicted)

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%