FOG00776
EOG88W9NK
EOG8J0ZRD
EOG8QJQ6M

sce:COX18

Genes: 29

Protein description
COX.02.assembly


SGD Description
Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC


PomBase Description
mitochondrial inner membrane protein Cox18


AspGD Description
Ortholog(s) have role in respiratory chain complex IV assembly and mitochondrial inner membrane localization


References

Hikkel I, et al. (1997 Oct). Cloning and characterization of KlCOX18, a gene required for activity of cytochrome oxidase in Kluyveromyces lactis.

Souza RL, et al. (2000 May 19). Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.

Saracco SA, et al. (2002 Apr). Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.

Gaisne M, et al. (2006 Sep). The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%

FOG00777
EOG8J0ZRD

sce:OXA1

Genes: 36

SGD Description
Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals


PomBase Description
mitochondrial inner membrane translocase Oxa101|mitochondrial inner membrane translocase Oxa102


AspGD Description
Ortholog(s) have ion channel activity, membrane insertase activity, mitochondrial ribosome binding activity


References

Bonnefoy N, et al. (1994 Jun 3). OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis.

Bauer M, et al. (1994 Nov 1). PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast.

Herrmann JM, et al. (1997 May 1). Insertion into the mitochondrial inner membrane of a polytopic protein, the nuclear-encoded Oxa1p.

Hell K, et al. (1998 Mar 3). Oxa1p, an essential component of the N-tail protein export machinery in mitochondria.

Bonnefoy N, et al. (2000 Mar). The respiratory gene OXA1 has two fission yeast orthologues which together encode a function essential for cellular viability.

Stuart R, et al. (2002 Sep 2). Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex.

Jia L, et al. (2003 Dec 15). Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Gaisne M, et al. (2006 Sep). The COX18 gene, involved in mitochondrial biogenesis, is functionally conserved and tightly regulated in humans and fission yeast.

Mathieu L, et al. (2010 Jan). A mutational analysis reveals new functional interactions between domains of the Oxa1 protein in Saccharomyces cerevisiae.

Ma Y, et al. (2011). Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Stoldt S, et al. (2012 Jun). The inner-mitochondrial distribution of Oxa1 depends on the growth conditions and on the availability of substrates.

Hildenbeutel M, et al. (2012 Nov 2). The membrane insertase Oxa1 is required for efficient import of carrier proteins into mitochondria.

Keil M, et al. (2012 Oct 5). Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria.

Krüger V, et al. (2012 Sep 28). The mitochondrial oxidase assembly protein1 (Oxa1) insertase forms a membrane pore in lipid bilayers.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Pfeffer S, et al. (2015 Jan 22). Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 36 genes with posterior transmembrane prediction > 50%

FOG00778
EOG8J0ZRD

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00779
EOG8QJQ6M

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%