FOG00634
EOG8TX976
SDH1
sce:SDH1

Genes: 34

Protein description
Flavoprotein subunit of succinate dehydrogenase


SGD Description
Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; SDH1 has a paralog, YJL045W, that arose from the whole genome duplication


PomBase Description
succinate dehydrogenase Sdh1 (predicted)


AspGD Description
Succinate dehydrogenase (ubiquinone)


References

Robinson KM, et al. (1992 May 15). Isolation and nucleotide sequence of the Saccharomyces cerevisiae gene for the succinate dehydrogenase flavoprotein subunit.

Chapman KB, et al. (1992 Sep 1). SDH1, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae.

Schülke N, et al. (1992 Sep 1). Primary structure, import, and assembly of the yeast homolog of succinate dehydrogenase flavoprotein.

Robinson KM, et al. (1994 Jun 15). The covalent attachment of FAD to the flavoprotein of Saccharomyces cerevisiae succinate dehydrogenase is not necessary for import and assembly into mitochondria.

Bullis BL, et al. (1994 Mar 4). Isolation and characterization of the Saccharomyces cerevisiae SDH4 gene encoding a membrane anchor subunit of succinate dehydrogenase.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Lemire BD, et al. (2002 Jan 17). The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase.

Oyedotun KS, et al. (2004 Mar 5). The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Hao HX, et al. (2009 Aug 28). SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Ohtsuka H, et al. (2013 Jun). Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

McDonald KR, et al. (2016 Sep). Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00635
EOG8TX976

sce:absent

Genes: 2

Parent
paralog:FOG00634

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00636


sce:absent

Genes: 1

Protein description
Involved in diauxic shift


Parent
ohnolog:FOG00634


SGD Description
Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication


References

Colby G, et al. (1998 Aug). Suppression of sdh1 mutations by the SDH1b gene of Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%