FOG00558
EOG83R252
GPD1
sce:GPD1

Genes: 27

Protein description
Cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase


Features
[c]


SGD Description
NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity; GPD1 has a paralog, GPD2, that arose from the whole genome duplication


PomBase Description
glycerol-3-phosphate dehydrogenase Gpd1|glycerol-3-phosphate dehydrogenase Gpd2


AspGD Description
Ortholog(s) have glycerol-3-phosphate dehydrogenase [NAD+] activity and role in NADH oxidation, cell-abiotic substrate adhesion, glycerol biosynthetic process, intracellular accumulation of glycerol


References

Sleep D, et al. (1991 May 15). Cloning and characterisation of the Saccharomyces cerevisiae glycerol-3-phosphate dehydrogenase (GUT2) promoter.

Larsson K, et al. (1993 Dec). A gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD+) complements an osmosensitive mutant of Saccharomyces cerevisiae.

Albertyn J, et al. (1994 Jun). GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway.

Wang HT, et al. (1994 Nov). Cloning, sequence, and disruption of the Saccharomyces diastaticus DAR1 gene encoding a glycerol-3-phosphate dehydrogenase.

Ohmiya R, et al. (1995 Dec). Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth.

Aiba H, et al. (1995 Dec 4). The osmo-inducible gpd1+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast.

Norbeck J, et al. (1996 Mar 15). Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae.

Yamada H, et al. (1996 May). Construction and characterization of a deletion mutant of gpd2 that encodes an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast.

Fillinger S, et al. (2001 Jan). Molecular and physiological characterization of the NAD-dependent glycerol 3-phosphate dehydrogenase in the filamentous fungus Aspergillus nidulans.

de Vries RP, et al. (2003 Jul). Glycerol dehydrogenase, encoded by gldB is essential for osmotolerance in Aspergillus nidulans.

Valadi A, et al. (2004 Sep 17). Distinct intracellular localization of Gpd1p and Gpd2p, the two yeast isoforms of NAD+-dependent glycerol-3-phosphate dehydrogenase, explains their different contributions to redox-driven glycerol production.

Aguilera J, et al. (2005 Apr). The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Balázs A, et al. (2010 Mar). AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00559
EOG83R252
GPD2
sce:GPD2

Genes: 17

Protein description
Mitochondrial NAD-dependent glycerol-3-phosphate dehydrogenase


Features
[m]


Parent
paralog:FOG00558


SGD Description
NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication


References

Eriksson P, et al. (1995 Jul). Cloning and characterization of GPD2, a second gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD+) in Saccharomyces cerevisiae, and its comparison with GPD1.

Björkqvist S, et al. (1997 Jan). Physiological response to anaerobicity of glycerol-3-phosphate dehydrogenase mutants of Saccharomyces cerevisiae.

Ansell R, et al. (1997 May 1). The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Valadi A, et al. (2004 Sep 17). Distinct intracellular localization of Gpd1p and Gpd2p, the two yeast isoforms of NAD+-dependent glycerol-3-phosphate dehydrogenase, explains their different contributions to redox-driven glycerol production.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00560
EOG83R252
GPD3
sce:absent

Genes: 2

Protein description
Mitochondrial NAD-dependent glycerol-3-phosphate dehydrogenase


Features
[m]


Parent
paralog:FOG00558


AspGD Description
Glycerol 3-phosphate dehydrogenase (NAD+ dependent)


References

Furukawa K, et al. (2007 Jul). Novel reporter gene expression systems for monitoring activation of the Aspergillus nidulans HOG pathway.

Hagiwara D, et al. (2008 Oct). Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Balázs A, et al. (2010 Mar). AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%