FOG00504
EOG89S4PZ
EOG8BCC55
EOG8T4BC4
EOG8XKSQQ

sce:ARI1

Genes: 140

SGD Description
NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily


PomBase Description
flavonol reductase/cinnamoyl-CoA reductase family


AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process|Ortholog(s) have carbonyl reductase (NADPH) activity and cytosol, nucleus localization|Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process


References

Katz M, et al. (2003 Dec 5). Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Liu ZL, et al. (2009 Oct 1). A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion.

Bowman MJ, et al. (2010 Aug). Stereochemistry of furfural reduction by a Saccharomyces cerevisiae aldehyde reductase that contributes to in situ furfural detoxification.

Sun X, et al. (2013 May). PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00505
EOG8BCC55

sce:absent

Genes: 1

SGD Description
Aldehyde reductase; substrates are both aromatic and aliphatic aldehydes; uses NADPH as cofactor

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00506
EOG8BCC55

sce:GRE2

Genes: 1

SGD Description
3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase


References

Murata K, et al. (1985 Sep 16). Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae.

Garay-Arroyo A, et al. (1999 Jul). Three genes whose expression is induced by stress in Saccharomyces cerevisiae.

Lee J, et al. (1999 Jun 4). Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast.

Rep M, et al. (2001 Jun). The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage.

Chen CN, et al. (2003 Apr 30). Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae.

Warringer J, et al. (2006 Apr 15). Involvement of yeast YOL151W/GRE2 in ergosterol metabolism.

Hauser M, et al. (2007 Jan). A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase.

Katzberg M, et al. (2010 Apr 14). Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.

Müller M, et al. (2010 Apr 7). Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae.

Choi YH, et al. (2010 Jun). Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity.

Guo PC, et al. (2014 Sep). Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00507
EOG8BCC55

sce:absent

Genes: 1

SGD Description
Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00508
EOG8BCC55
EOG8W6MCC

sce:absent

Genes: 11

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process|Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00509
EOG8BCC55

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process


References

Sun X, et al. (2013 May). PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00510
EOG8BCC55

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00511
EOG8BCC55

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process|Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00512
EOG8BCC55
EOG8XKSQQ

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00513
EOG8BCC55

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00514
EOG82V6ZW
EOG8W6MCC

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00515
EOG82V6ZW
EOG8NK9C3
EOG8QRFMP
EOG8W9GMJ

sce:absent

Genes: 5

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00516
EOG82V6ZW
EOG8R4XM2

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted 3-beta-hydroxy-delta5-steroid dehydrogenase activity and role in oxidation-reduction process, steroid biosynthetic process|Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00517
EOG8KKWK8
EOG8XKSQQ

sce:absent

Genes: 4

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process|Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00518
EOG82V6ZW

sce:absent

Genes: 3

AspGD Description
Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process|Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00519
EOG8T4BC4
EOG8Z34XX

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00520
EOG8BCC55

sce:absent

Genes: 10

PomBase Description
methylglyoxyl reductase (NADPH-dependent) (predicted)


References

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%