FOG00499
EOG8GMSCP
EOG8S4MZ3
ADH4
sce:absent

Genes: 10

Protein description
Alcohol dehydrogenase isoenzyme type IV


Features
[m]


PomBase Description
alcohol dehydrogenase Adh4


AspGD Description
Has domain(s) with predicted metal ion binding, oxidoreductase activity and role in oxidation-reduction process


Suggested Analysis
Investigate if gene if a xenolog from a bacterial species


References

Schuurink R, et al. (1990 Jun). Purification and properties of NADP(+)-dependent glycerol dehydrogenases from Aspergillus nidulans and A. niger.

Sakurai M, et al. (2004 Mar). A distinct type of alcohol dehydrogenase, adh4+, complements ethanol fermentation in an adh1-deficient strain of Schizosaccharomyces pombe.

Crichton PG, et al. (2007 Jan 15). Identification of a mitochondrial alcohol dehydrogenase in Schizosaccharomyces pombe: new insights into energy metabolism.

Hortschansky P, et al. (2007 Jul 11). Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.

Dainty SJ, et al. (2008 Mar). Response of Schizosaccharomyces pombe to zinc deficiency.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Corkins ME, et al. (2013 Sep 17). Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00500
EOG8S4MZ3
ADH4.2
sce:ADH4

Genes: 3

Protein description
Alcohol dehydrogenase isoenzyme type IV, horizontal gene transfer from spo


Features
[m]


Parent
xenolog:FOG00499


SGD Description
Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency


References

Williamson VM, et al. (1987 Sep). Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis.

Drewke C, et al. (1988 May 6). Overexpression, purification and properties of alcohol dehydrogenase IV from Saccharomyces cerevisiae.

Lyons TJ, et al. (2000 Jul 5). Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast.

Yuan DS, et al. (2000 Sep). Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging.

Bird AJ, et al. (2006 Dec 13). Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts.

Mizuno A, et al. (2006 Jan). Characterization of low-acetic-acid-producing yeast isolated from 2-deoxyglucose-resistant mutants and its application to high-gravity brewing.

De Nicola R, et al. (2007 Dec). Physiological and transcriptional responses of Saccharomyces cerevisiae to zinc limitation in chemostat cultures.

Cheraiti N, et al. (2008 Jan). Acetaldehyde addition throughout the growth phase alleviates the phenotypic effect of zinc deficiency in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%