FOG00443
EOG81RN97
EOG86Q583
EOG8HDR9F

sce:ATF2

Genes: 10

Protein description
Alcohol acetyltransferase


SGD Description
Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00442
EOG86Q583

sce:ATF1

Genes: 1

Protein description
Alcohol acetyltransferase


Parent
ohnolog:FOG00443


SGD Description
Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism


References

Minetoki T, et al. (1993 Dec). The purification, properties and internal peptide sequences of alcohol acetyltransferase isolated from Saccharomyces cerevisiae Kyokai No. 7.

Fujii T, et al. (1994 Aug). Molecular cloning, sequence analysis, and expression of the yeast alcohol acetyltransferase gene.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00444
EOG8HDR9F

sce:absent

Genes: 10

Suggested Analysis
consolidate

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00445
EOG81RN97
EOG8W6MBB

sce:CDC4

Genes: 36

SGD Description
F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p


PomBase Description
F-box/WD repeat protein Pop2|cullin 1 adaptor protein Pop1


AspGD Description
Ortholog(s) have protein binding, bridging, ubiquitin-protein transferase activity


References

Yochem J, et al. (1987 May 20). Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene.

Kornitzer D, et al. (1994 Dec 15). Regulated degradation of the transcription factor Gcn4.

Bai C, et al. (1996 Jul 26). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.

Drury LS, et al. (1997 Oct 1). The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast.

Feldman RM, et al. (1997 Oct 17). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.

Skowyra D, et al. (1997 Oct 17). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.

Li FN, et al. (1997 Sep 15). Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle.

Patton EE, et al. (1998 Mar 1). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.

Jaquenoud M, et al. (1998 Sep 15). The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex.

Skowyra D, et al. (1999 Apr 23). Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

Goh PY, et al. (1999 Aug). Cdc4, a protein required for the onset of S phase, serves an essential function during G(2)/M transition in Saccharomyces cerevisiae.

Seol JH, et al. (1999 Jun 15). Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.

Blondel M, et al. (2000 Nov 15). Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

Jäger S, et al. (2001 Aug 15). Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.

Kus BM, et al. (2004 Feb 15). Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.

Hao B, et al. (2007 Apr 13). Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.

Colabardini AC, et al. (2012 Feb). Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00446
EOG81RN97

sce:PFS2

Genes: 34

SGD Description
Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex


PomBase Description
WD repeat protein Pfs2


AspGD Description
Ortholog(s) have role in mRNA 3'-end processing and cytosol, mRNA cleavage and polyadenylation specificity factor complex, nuclear chromatin localization


References

Ohnacker M, et al. (2000 Jan 4). The WD-repeat protein pfs2p bridges two essential factors within the yeast pre-mRNA 3'-end-processing complex.

Nedea E, et al. (2003 Aug 29). Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00447
EOG81RN97

sce:PRP4

Genes: 34

SGD Description
Splicing factor; component of the U4/U6-U5 snRNP complex


PomBase Description
U4/U6 x U5 tri-snRNP complex subunit Prp4 family, Rna4


AspGD Description
Ortholog(s) have U4/U6 x U5 tri-snRNP complex, cytosol localization


References

Banroques J, et al. (1989 Sep). PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle.

Bjørn SP, et al. (1989 Sep). PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle.

Gottschalk A, et al. (1999 Aug 16). Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.

Carnahan RH, et al. (2005 Mar). Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00448
EOG81RN97

sce:TAF5

Genes: 34

SGD Description
Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification


PomBase Description
SAGA complex subunit/TATA-binding protein associated factor/transcription factor TFIID complex subunit Taf5


AspGD Description
Ortholog(s) have SAGA complex localization


References

Reese JC, et al. (1994 Oct 6). Yeast TAFIIS in a multisubunit complex required for activated transcription.

Poon D, et al. (1995 Aug 29). Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.

Grant PA, et al. (1998 Jul 10). A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Sanders SL, et al. (2000 May 5). Identification of two novel TAF subunits of the yeast Saccharomyces cerevisiae TFIID complex.

Sanders SL, et al. (2002 Aug). Molecular characterization of Saccharomyces cerevisiae TFIID.

Martinez E, et al. (2002 Dec). Multi-protein complexes in eukaryotic gene transcription.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Sanders SL, et al. (2002 Jul). Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry.

Leurent C, et al. (2002 Jul 1). Mapping histone fold TAFs within yeast TFIID.

Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG00449
EOG83TXBC
EOG8W6MBB

sce:TUP1

Genes: 34

SGD Description
General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes


PomBase Description
transcriptional corepressor Tup11|transcriptional corepressor Tup12


AspGD Description
Protein of unknown function|Transcriptional repressor that controls expression of genes involved in cell wall biosynthesis, development, and nitrogen source utilization


References

Fujita A, et al. (1990 Apr 30). Cloning of the yeast SFL2 gene: its disruption results in pleiotropic phenotypes characteristic for tup1 mutants.

Williams FE, et al. (1990 Dec). Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.

Kearsey S, et al. (1991 Feb 1). The SFL2 (TUP1?) protein of Saccharomyces cerevisiae contains a repeating motif homologous to beta subunits of G proteins.

Zhang M, et al. (1991 Jan 15). A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes.

Komachi K, et al. (1994 Dec 1). The WD repeats of Tup1 interact with the homeo domain protein alpha 2.

Varanasi US, et al. (1996 Dec). The Cyc8 (Ssn6)-Tup1 corepressor complex is composed of one Cyc8 and four Tup1 subunits.

Edmondson DG, et al. (1996 May 15). Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

Braun BR, et al. (1997 Jul 4). Control of filament formation in Candida albicans by the transcriptional repressor TUP1.

Hoover CI, et al. (1998 Oct 15). Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene.

Huang M, et al. (1998 Sep 4). The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.

Mukai Y, et al. (1999 Dec). Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog.

Phan QT, et al. (2000 Jun). Role of hyphal formation in interactions of Candida albicans with endothelial cells.

Sprague ER, et al. (2000 Jun 15). Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast.

Papamichos-Chronakis M, et al. (2000 Mar 24). Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme.

Braun BR, et al. (2000 May). TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicans.

Watson AD, et al. (2000 Nov 1). Ssn6-Tup1 interacts with class I histone deacetylases required for repression.

Braun BR, et al. (2000 Sep). Identification and characterization of TUP1-regulated genes in Candida albicans.

Kadosh D, et al. (2001 Apr). Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans.

Wu J, et al. (2001 Jan). TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast.

Taricani L, et al. (2001 Jul 15). Expression of hsp16 in response to nucleotide depletion is regulated via the spc1 MAPK pathway in Schizosaccharomyces pombe.

Hicks J, et al. (2001 Mar). RcoA has pleiotropic effects on Aspergillus nidulans cellular development.

Janoo RT, et al. (2001 Mar). Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Proft M, et al. (2001 Mar 1). Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress.

Murad AM, et al. (2001 Nov). Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.

Pascual-Ahuir A, et al. (2001 Oct 5). Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress.

Murad AM, et al. (2001 Sep 3). NRG1 represses yeast-hypha morphogenesis and hypha-specific gene expression in Candida albicans.

Davie JK, et al. (2002 Feb). Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo.

Zhao R, et al. (2002 Jun). Roles of TUP1 in switching, phase maintenance, and phase-specific gene expression in Candida albicans.

Pelletier B, et al. (2002 Jun 21). Fep1, an iron sensor regulating iron transporter gene expression in Schizosaccharomyces pombe.

Greenall A, et al. (2002 Sep). Role of fission yeast Tup1-like repressors and Prr1 transcription factor in response to salt stress.

Todd RB, et al. (2003 Apr). TupA, the Penicillium marneffei Tup1p homologue, represses both yeast and spore development.

Mennella TA, et al. (2003 Dec). Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.

Davie JK, et al. (2003 Dec 12). Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.

Mukai Y, et al. (2003 May 23). Physical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase.

Hirota K, et al. (2003 Oct). Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot.

Hirota K, et al. (2004). Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses.

Park YN, et al. (2005 Dec). Candida albicans MTLalpha tup1Delta mutants can reversibly switch to mating-competent, filamentous growth forms.

Cao YY, et al. (2005 Feb). cDNA microarray analysis of differential gene expression in Candida albicans biofilm exposed to farnesol.

Fagerström-Billai F, et al. (2005 Jan). Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast.

Kadosh D, et al. (2005 Jun). Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysis.

Todd RB, et al. (2006 Nov). The Aspergillus nidulans rcoA gene is required for veA-dependent sexual development.

Fagerström-Billai F, et al. (2007 Feb). Individual subunits of the Ssn6-Tup11/12 corepressor are selectively required for repression of different target genes.

Monahan BJ, et al. (2008 Aug). Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

García I, et al. (2008 Dec). Roles of the Aspergillus nidulans homologues of Tup1 and Ssn6 in chromatin structure and cell viability.

Calvo AM, et al. (2008 Jul). The VeA regulatory system and its role in morphological and chemical development in fungi.

Kebaara BW, et al. (2008 Jun). Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Han KH, et al. (2009 Sep). Molecular Genetics of Emericella nidulans Sexual Development.

Kang WH, et al. (2010 Apr 30). The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe.

Matsuzawa T, et al. (2010 Jun). The gld1+ gene encoding glycerol dehydrogenase is required for glycerol metabolism in Schizosaccharomyces pombe.

Ferreira ME, et al. (2010 Jun 8). WD40 domain divergence is important for functional differences between the fission yeast Tup11 and Tup12 co-repressor proteins.

Matsuzawa T, et al. (2011 Dec). Identification of a galactose-specific flocculin essential for non-sexual flocculation and filamentous growth in Schizosaccharomyces pombe.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.

Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Kitamura K, et al. (2012 Mar). The Ubiquitin ligase Ubr11 is essential for oligopeptide utilization in the fission yeast Schizosaccharomyces pombe.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Zhang L, et al. (2013). Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Sun X, et al. (2013 May). PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Dzikowska A, et al. (2015 Dec 1). KAEA (SUDPRO), a member of the ubiquitous KEOPS/EKC protein complex, regulates the arginine catabolic pathway and the expression of several other genes in Aspergillus nidulans.

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Asada R, et al. (2015 Mar). Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor.

Tang MY, et al. (2015 May 10). Two fission yeast high mobility group box proteins in the maintenance of genomic integrity following doxorubicin insult.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00450
EOG81RN97

sce:RSA4

Genes: 33

SGD Description
WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus


PomBase Description
notchless-like protein (predicted)


AspGD Description
Ortholog(s) have role in cellular response to drug, ribosomal large subunit assembly and nucleolus, ribosome localization


References

de la Cruz J, et al. (2005). The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits.

Fleischer TC, et al. (2006 May 15). Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Lebreton A, et al. (2008 Sep). 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes.

Ulbrich C, et al. (2009 Sep 4). Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits.

Bassler J, et al. (2010 Jun 11). The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Leidig C, et al. (2014 Mar 24). 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.

Baßler J, et al. (2014 Nov 24). A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.

Baßler J, et al. (2015 Jul 6). A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.

Barrio-Garcia C, et al. (2016 Jan). Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.

Wu S, et al. (2016 Jun 2). Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00451
EOG81RN97

sce:ASC1

Genes: 33

SGD Description
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation


PomBase Description
RACK1 ortholog Cpc2


AspGD Description
Ortholog(s) have G-protein alpha-subunit binding, GDP-dissociation inhibitor activity, protein kinase C binding, ribosome binding activity


References

Norbeck J, et al. (1997 Feb 28). Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway.

Hoffmann B, et al. (2000 Jul). c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans.

Melin P, et al. (2002 Aug). Proteome analysis of Aspergillus nidulans reveals proteins associated with the response to the antibiotic concanamycin A, produced by Streptomyces species.

Baum S, et al. (2004 Jun 15). Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Sengupta J, et al. (2004 Oct). Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.

Gerbasi VR, et al. (2004 Sep). Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Liu X, et al. (2010 Nov). Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans.

Ben-Shem A, et al. (2010 Nov 26). Crystal structure of the eukaryotic ribosome.

Yatime L, et al. (2011 Aug 12). Structure of the RACK1 dimer from Saccharomyces cerevisiae.

Ben-Shem A, et al. (2011 Dec 16). The structure of the eukaryotic ribosome at 3.0 Å resolution.

Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.

Freitas JS, et al. (2011 Sep). Transcription of the Hsp30, Hsp70, and Hsp90 heat shock protein genes is modulated by the PalA protein in response to acid pH-sensing in the fungus Aspergillus nidulans.

Park HS, et al. (2012 Dec). Genetic control of asexual sporulation in filamentous fungi.

Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Kong Q, et al. (2013). Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus.

Martins I, et al. (2013 Dec 6). Proteomic alterations induced by ionic liquids in Aspergillus nidulans and Neurospora crassa.

Ban N, et al. (2014 Feb). A new system for naming ribosomal proteins.

Hussain T, et al. (2014 Oct 23). Structural changes enable start codon recognition by the eukaryotic translation initiation complex.

Cai ZD, et al. (2015 Aug). The Gβ-like protein CpcB is required for hyphal growth, conidiophore morphology and pathogenicity in Aspergillus fumigatus.

Llácer JL, et al. (2015 Aug 6). Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.

Murray J, et al. (2016 May 9). Structural characterization of ribosome recruitment and translocation by type IV IRES.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00452
EOG81RN97

sce:SEC27

Genes: 33

SGD Description
Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP


PomBase Description
coatomer beta' subunit (predicted)


AspGD Description
COPI complex, beta' subunit; expression enhanced by maltose


References

Harter C, et al. (1993 Oct 11). Yeast coatomer contains a subunit homologous to mammalian beta'-COP.

Duden R, et al. (1994 Sep 30). Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Gabriely G, et al. (2007 Jan). Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00453
EOG8W6MBB

sce:SWD3

Genes: 33

SGD Description
Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5


PomBase Description
WD repeat protein Swd3


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN3926, A. fumigatus Af293 : Afu6g08380, A. oryzae RIB40 : AO090003000092, Aspergillus wentii : Aspwe1_0045950 and Aspergillus sydowii : Aspsy1_0044421


References

Roguev A, et al. (2001 Dec 17). The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.

Miller T, et al. (2001 Nov 6). COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.

Krogan NJ, et al. (2002 Mar 29). COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00454
EOG81RN97

sce:COP1

Genes: 33

SGD Description
Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway


PomBase Description
coatomer alpha subunit Cop1 (predicted)


AspGD Description
COPI complex. alpha subunit; expression enhanced by maltose


References

Letourneur F, et al. (1994 Dec 30). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.

Gerich B, et al. (1995 Apr 11). Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth.

Gabriely G, et al. (2007 Jan). Involvement of specific COPI subunits in protein sorting from the late endosome to the vacuole in yeast.

Sato K, et al. (2009 Oct). Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00455
EOG81RN97

sce:MET30

Genes: 33

SGD Description
F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p


PomBase Description
F-box/WD repeat protein protein Pof1


AspGD Description
Ortholog(s) have protein binding, bridging, ubiquitin binding activity


References

Paszewski A, et al. (1994). Sulphur metabolism.

Thomas D, et al. (1995 Dec). Met30p, a yeast transcriptional inhibitor that responds to S-adenosylmethionine, is an essential protein with WD40 repeats.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Natorff R, et al. (1998 Feb). The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box.

Patton EE, et al. (1998 Mar 1). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.

Rouillon A, et al. (2000 Jan 17). Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCF(Met30 )complex.

Smothers DB, et al. (2000 Nov). The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.

Piotrowska M, et al. (2000 Oct). sconC, a gene involved in the regulation of sulphur metabolism in Aspergillus nidulans, belongs to the SKP1 gene family.

Ikebe C, et al. (2002 Feb 8). Isolation and characterization of a novel F-box protein Pof10 in fission yeast.

Natorff R, et al. (2003 Aug). The Aspergillus nidulans metR gene encodes a bZIP protein which activates transcription of sulphur metabolism genes.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Brunson LE, et al. (2004 Feb 20). The amino-terminal portion of the F-box protein Met30p mediates its nuclear import and assimilation into an SCF complex.

Lehmann A, et al. (2004 May). Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Yen JL, et al. (2005 Apr). The yeast ubiquitin ligase SCFMet30 regulates heavy metal response.

Harrison C, et al. (2005 Feb 9). SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast.

Brunson LE, et al. (2005 Jun). Identification of residues in the WD-40 repeat motif of the F-box protein Met30p required for interaction with its substrate Met4p.

Su NY, et al. (2005 May). The F-box protein Met30 is required for multiple steps in the budding yeast cell cycle.

Sieńko M, et al. (2007 Jul). Two Aspergillus nidulans genes encoding methylenetetrahydrofolate reductases are up-regulated by homocysteine.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Schmidt MW, et al. (2009 Sep 11). F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

Brzywczy J, et al. (2011 Feb). Novel mutations reveal two important regions in Aspergillus nidulans transcriptional activator MetR.

Colabardini AC, et al. (2012 Feb). Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction.

Wu S, et al. (2013). CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Sieńko M, et al. (2014 Apr). Regulatory mutations affecting sulfur metabolism induce environmental stress response in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00456
EOG81RN97

sce:PAC1

Genes: 31

SGD Description
Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly


AspGD Description
Ortholog(s) have microtubule plus-end binding activity


References

Xiang X, et al. (1995). Analysis of nuclear migration in Aspergillus nidulans.

Willins DA, et al. (1995 Dec). An alpha tubulin mutation suppresses nuclear migration mutations in Aspergillus nidulans.

Morris NR, et al. (1995 Jul). Nuclear migration advances in fungi.

Xiang X, et al. (1995 Mar). NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.

Chiu YH, et al. (1995 Oct). Extragenic suppressors of nudC3, a mutation that blocks nuclear migration in Aspergillus nidulans.

Xiang X, et al. (1995 Oct 10). Characterization and localization of the cytoplasmic dynein heavy chain in Aspergillus nidulans.

Wolkow TD, et al. (1996 Aug). Cytokinesis in Aspergillus nidulans is controlled by cell size, nuclear positioning and mitosis.

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Morris SM, et al. (1997 Feb). A prolactin-inducible T cell gene product is structurally similar to the Aspergillus nidulans nuclear movement protein NUDC.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Geiser JR, et al. (1997 Jun). Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.

Willins DA, et al. (1997 Jun). Mutations in the heavy chain of cytoplasmic dynein suppress the nudF nuclear migration mutation of Aspergillus nidulans.

Morris NR, et al. (1998 Dec). Nuclear migration, nucleokinesis and lissencephaly.

Fischer R, et al. (1999 Jan). Nuclear movement in filamentous fungi.

Liu Z, et al. (1999 Oct). Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation.

Efimov VP, et al. (2000 Aug 7). The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein.

Feng Y, et al. (2000 Dec). LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.

Niethammer M, et al. (2000 Dec). NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.

Ahn C, et al. (2001 Mar 30). Nudf, a fungal homolog of the human LIS1 protein, functions as a dimer in vivo.

Han G, et al. (2001 May 1). The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics.

Hoffmann B, et al. (2001 Oct 19). The LIS1-related protein NUDF of Aspergillus nidulans and its interaction partner NUDE bind directly to specific subunits of dynein and dynactin and to alpha- and gamma-tubulin.

Dawe AL, et al. (2001 Sep). Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans.

Zhang J, et al. (2002 Apr). Cytoplasmic dynein intermediate chain and heavy chain are dependent upon each other for microtubule end localization in Aspergillus nidulans.

Zhang J, et al. (2003 Apr). Accumulation of cytoplasmic dynein and dynactin at microtubule plus ends in Aspergillus nidulans is kinesin dependent.

Lee WL, et al. (2003 Feb 3). The role of the lissencephaly protein Pac1 during nuclear migration in budding yeast.

Efimov VP, et al. (2003 Mar). Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects.

Xiang X, et al. (2004 Apr). Nuclear migration and positioning in filamentous fungi.

Hoffmann B, et al. (2004 Jan 2). The LIS1-related protein NUDF of Aspergillus nidulans and its interaction partner NUDE bind directly to specific subunits of dynein and dynactin and to alpha- and gamma-tubulin.

Holzbaur EL, et al. (2004 Jul). Tangled NUDELs?

Li S, et al. (2005 Aug). Cytoplasmic dynein's mitotic spindle pole localization requires a functional anaphase-promoting complex, gamma-tubulin, and NUDF/LIS1 in Aspergillus nidulans.

Veith D, et al. (2005 Aug 15). Role of the spindle-pole-body protein ApsB and the cortex protein ApsA in microtubule organization and nuclear migration in Aspergillus nidulans.

Li J, et al. (2005 Jul). NudEL targets dynein to microtubule ends through LIS1.

Efimov VP, et al. (2006 Apr). CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans.

Enke C, et al. (2007 Mar). Aspergillus nidulans Dis1/XMAP215 protein AlpA localizes to spindle pole bodies and microtubule plus ends and contributes to growth directionality.

Zhuang L, et al. (2007 Mar). Point mutations in the stem region and the fourth AAA domain of cytoplasmic dynein heavy chain partially suppress the phenotype of NUDF/LIS1 loss in Aspergillus nidulans.

Helmstaedt K, et al. (2008 Jun). The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies.

Fischer R, et al. (2008 May). Polarized growth in fungi--interplay between the cytoskeleton, positional markers and membrane domains.

Markus SM, et al. (2009 Feb 10). Motor- and tail-dependent targeting of dynein to microtubule plus ends and the cell cortex.

Zhang J, et al. (2010 Oct 15). The microtubule plus-end localization of Aspergillus dynein is important for dynein-early-endosome interaction but not for dynein ATPase activation.

Zhu XJ, et al. (2010 Sep 24). The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.

Zhang J, et al. (2011 Jun 27). The p25 subunit of the dynactin complex is required for dynein-early endosome interaction.

Egan MJ, et al. (2012 Dec). Microtubule-based transport in filamentous fungi.

Peñalva MA, et al. (2012 Jan 1). Searching for gold beyond mitosis: Mining intracellular membrane traffic in Aspergillus nidulans.

Qiu R, et al. (2013 Jan 25). Identification of a novel site in the tail of dynein heavy chain important for dynein function in vivo.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00457
EOG81RN97

sce:LST8

Genes: 31

SGD Description
Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat


PomBase Description
WD repeat protein Pop3


AspGD Description
Ortholog(s) have role in microtubule cytoskeleton organization, mitotic sister chromatid segregation and TORC1 complex, TORC2 complex, cytosol, nucleus localization


References

Nurse P, et al. (1976 Jul 23). Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Bañuelos M, et al. (1977 Sep 25). Activation by phosphate of yeast phosphofructokinase.

Streiblová E, et al. (1984 Jul). Septum pattern in ts mutants of Schizosaccharomyces pombe defective in genes cdc3, cdc4, cdc8 and cdc12.

Roberg KJ, et al. (1997 Dec). Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8.

Kemp JT, et al. (1997 Mar 26). A wat1 mutant of fission yeast is defective in cell morphology.

Ochotorena IL, et al. (2001 Aug). Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation.

Liu Z, et al. (2001 Dec 17). RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p.

Loewith R, et al. (2002 Sep). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Chen EJ, et al. (2003 Apr 28). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway.

Wedaman KP, et al. (2003 Mar). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.

Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Wullschleger S, et al. (2005 Sep 2). Molecular organization of target of rapamycin complex 2.

Alvarez B, et al. (2006 Nov 1). Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Matsuo T, et al. (2007 Apr). Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Hayashi T, et al. (2007 Dec). Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Kanoh J, et al. (2007 Dec). Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

Ikeda K, et al. (2008 Feb 1). Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Tatebe H, et al. (2010 Nov 23). Rab-family GTPase regulates TOR complex 2 signaling in fission yeast.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Cortés JC, et al. (2012 Aug 20). Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Nakashima A, et al. (2012 Dec 1). Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Verma SK, et al. (2014). Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Hatano T, et al. (2015). Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Saitoh S, et al. (2015 Jan 15). Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Baker K, et al. (2016 Jul 1). TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis.

Tatebe H, et al. (2017 Mar 7). Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00458
EOG8W6MBB

sce:MDV1

Genes: 27

SGD Description
Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication


PomBase Description
CCR4-Not complex subunit Caf4/Mdv1 (predicted)


AspGD Description
Ortholog(s) have ubiquitin binding activity, role in mitochondrial fission, mitochondrial genome maintenance, peroxisome fission and mitochondrial outer membrane localization


References

Fekkes P, et al. (2000 Oct 16). Gag3p, an outer membrane protein required for fission of mitochondrial tubules.

Mozdy AD, et al. (2000 Oct 16). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.

Tieu Q, et al. (2000 Oct 16). Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division.

Tieu Q, et al. (2002 Aug 5). The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission.

Cerveny KL, et al. (2003 Oct). The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria.

Griffin EE, et al. (2005 Jul 18). The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.

Suzuki M, et al. (2005 Jun 3). Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.

Karren MA, et al. (2005 Oct 24). The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly.

Naylor K, et al. (2006 Jan 27). Mdv1 interacts with assembled dnm1 to promote mitochondrial division.

Bhar D, et al. (2006 Jun 23). Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Koirala S, et al. (2013 Apr 9). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00459
EOG812JNC
EOG81RN97
EOG8K6DK2
EOG8KPRTF
EOG8RV164
EOG8SBCFX
EOG8T1G2H

sce:absent

Genes: 12

AspGD Description
Has domain(s) with predicted ADP binding, catalytic activity, microtubule motor activity, nucleoside-triphosphatase activity, nucleotide binding activity, role in nucleoside metabolic process and kinesin complex localization|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted ADP binding, catalytic activity and role in defense response, nucleoside metabolic process|Ortholog of A. fumigatus Af293 : Afu6g09450, Neosartorya fischeri NRRL 181 : NFIA_112440, Aspergillus wentii : Aspwe1_0731886 and Aspergillus versicolor : Aspve1_0056875, Aspve1_0755767|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted ADP binding, catalytic activity, microtubule motor activity, nucleoside-triphosphatase activity, nucleotide binding activity, role in nucleoside metabolic process and kinesin complex localization|Has domain(s) with predicted ADP binding, catalytic activity and role in defense response, nucleoside metabolic process|Ortholog of A. oryzae RIB40 : AO090038000491, Aspergillus wentii : Aspwe1_0036466, Aspergillus clavatus NRRL 1 : ACLA_041520 and Aspergillus niger ATCC 1015 : 55214-mRNA|Has domain(s) with predicted ADP binding, catalytic activity and role in defense response, nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process


References

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG00460
EOG870RZR
EOG8KPRTF

sce:absent

Genes: 12

AspGD Description
Has domain(s) with predicted ADP binding, catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process


References

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00461
EOG81RN97
EOG8W6MBB

sce:absent

Genes: 10

PomBase Description
F-box protein Pof11


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN2861, A. fumigatus Af293 : Afu3g11870, A. oryzae RIB40 : AO090003000750, Aspergillus wentii : Aspwe1_0105255 and Aspergillus sydowii : Aspsy1_0042742


References

Lehmann A, et al. (2004 May). Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Colabardini AC, et al. (2012 Feb). Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction.

Wu S, et al. (2013). CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00462
EOG8W6MBB

sce:absent

Genes: 9

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN6217, A. fumigatus Af293 : Afu2g12060, A. oryzae RIB40 : AO090026000440, Aspergillus wentii : Aspwe1_0053972 and Aspergillus sydowii : Aspsy1_0152133

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00463
EOG81RN97

sce:absent

Genes: 8

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Ortholog of A. niger CBS 513.88 : An08g12200, Aspergillus flavus NRRL 3357 : AFL2T_08825, Neosartorya fischeri NRRL 181 : NFIA_005170 and Aspergillus wentii : Aspwe1_0161656|Ortholog of A. nidulans FGSC A4 : AN8468, AN2021, A. fumigatus Af293 : Afu7g00550 and A. niger CBS 513.88 : An15g05630, An11g03460, An11g07530, An09g00640|Ortholog of A. nidulans FGSC A4 : AN8468, AN2021, A. fumigatus Af293 : Afu7g00550 and A. niger CBS 513.88 : An15g05630, An11g03460, An11g07530, An04g03850|Ortholog of A. nidulans FGSC A4 : AN8468, AN2021, A. fumigatus Af293 : Afu7g00550 and A. niger CBS 513.88 : An15g05630, An11g03460, An04g03850, An09g00640

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%

FOG00464
EOG81RN97
EOG8NCJTH

sce:absent

Genes: 8

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN8468, AN2021, A. fumigatus Af293 : Afu7g00550 and A. niger CBS 513.88 : An15g05630, An11g07530, An04g03850, An09g00640

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00465
EOG8T1G2H

sce:absent

Genes: 6

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Ortholog of A. niger CBS 513.88 : An01g01380, A. oryzae RIB40 : AO090038000267, Aspergillus niger ATCC 1015 : 36409-mRNA, Aspergillus zonatus : Aspzo1_0017959 and Aspergillus terreus NIH2624 : ATET_06412|Ortholog of Aspergillus tubingensis : Asptu1_0061269, Aspergillus kawachii : Aspka1_0181383 and Aspergillus acidus : Aspfo1_0064915

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00466
EOG8BVQBN
EOG8KPRTF
EOG8WWQ6N

sce:absent

Genes: 5

AspGD Description
Protein of unknown function|Ortholog of Aspergillus niger ATCC 1015 : 52980-mRNA and Aspergillus aculeatus ATCC16872 : Aacu16872_029599|Has domain(s) with predicted cysteine-type endopeptidase activity and role in proteolysis|Ortholog of A. oryzae RIB40 : AO090012000390, AO090009000464, Aspergillus brasiliensis : Aspbr1_0130524, Aspergillus flavus NRRL 3357 : AFL2T_03297 and Neosartorya fischeri NRRL 181 : NFIA_006040|Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00467
EOG847D82
EOG8KKWHW
EOG8KPRTF

sce:absent

Genes: 4

AspGD Description
Ortholog of A. nidulans FGSC A4 : AN10921, A. fumigatus Af293 : Afu3g07460, Neosartorya fischeri NRRL 181 : NFIA_069710 and Aspergillus niger ATCC 1015 : 119074-mRNA

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00468
EOG8T1G2H

sce:absent

Genes: 4

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00469
EOG8W6MBB

sce:absent

Genes: 4

AspGD Description
Ortholog(s) have role in cellular response to light stimulus, protein ubiquitination, regulation of circadian rhythm and SCF ubiquitin ligase complex, cytosol localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00470
EOG8KPRTF

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00471
EOG8KPRTF

sce:absent

Genes: 2

AspGD Description
Protein of unknown function|Ortholog of Aspergillus tubingensis : Asptu1_0120187

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00472
EOG84J10K
EOG8K6DK2

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted ADP binding, catalytic activity and role in defense response, nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00473
EOG8T1G2H

sce:absent

Genes: 2

AspGD Description
Ortholog of Aspergillus tubingensis : Asptu1_0109568 and Aspergillus kawachii : Aspka1_0176829|Ortholog of A. nidulans FGSC A4 : AN5168, AN1130, A. fumigatus Af293 : Afu6g07030, Afu4g13872, A. niger CBS 513.88 : An07g01930 and A. oryzae RIB40 : AO090701000916

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00474
EOG8J0ZX2
EOG8T1G2H

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00475
EOG8T1G2H

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00476
EOG8K6DK2

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00477
EOG8KPRTF

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00478
EOG870RZR

sce:absent

Genes: 2

AspGD Description
Ortholog of A. niger CBS 513.88 : An16g06750, A. oryzae RIB40 : AO090120000239, Aspergillus wentii : Aspwe1_0027728 and Aspergillus versicolor : Aspve1_0055646, Aspve1_0145949

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00479
EOG8T1G2H

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00480
EOG8W6MBB

sce:CAF4;RRT13

Genes: 6

SGD Description
WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication|Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription


References

Liu HY, et al. (2001 Mar 9). Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Griffin EE, et al. (2005 Jul 18). The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.

Schauss AC, et al. (2006 Aug 1). Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.

Zhang Y, et al. (2007 Nov 20). Structural basis for recruitment of mitochondrial fission complexes by Fis1.

Hontz RD, et al. (2009 May). Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00481
EOG8KPRTF

sce:absent

Genes: 10

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted microtubule motor activity and kinesin complex localization|Has domain(s) with predicted ADP binding activity|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted microtubule motor activity and kinesin complex localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00482
EOG8K6DK2

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process|Has domain(s) with predicted catalytic activity and role in nucleoside metabolic process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00483
EOG8KKWHW

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00484
EOG8RV164

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00485
EOG81RN97

sce:absent

Genes: 9

PomBase Description
transcription factor TFIID complex subunit Taf5-like


AspGD Description
Protein of unknown function|Ortholog of Aspergillus tubingensis : Asptu1_0122161, Aspergillus kawachii : Aspka1_0174991, Aspergillus acidus : Aspfo1_0162529 and Aspergillus niger ATCC 1015 : 41351-mRNA|Ortholog of A. nidulans FGSC A4 : AN8468, AN2021, A. fumigatus Af293 : Afu7g00550 and A. niger CBS 513.88 : An11g03460, An11g07530, An04g03850, An09g00640

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG00486
EOG812JNC

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted nucleoside-triphosphatase activity, nucleotide binding activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%