FOG00411
EOG84XH0C
ARA1
sce:ARA1

Genes: 30

SGD Description
NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product


References

Martínez-Soriano JP, et al. (1991 Feb 20). A widely distributed "CAT" family of repetitive DNA sequences.

Kim ST, et al. (1998 Dec 8). D-arabinose dehydrogenase and its gene from Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00412
EOG84XH0C

sce:absent

Genes: 33

SGD Description
NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress


PomBase Description
NADH/NADPH dependent indole-3-acetaldehyde reductase


AspGD Description
Ortholog(s) have alditol:NADP+ 1-oxidoreductase activity, alpha-keto amide reductase activity, alpha-keto ester reductase activity and indole-3-acetaldehyde reductase (NADH) activity, more


References

Petrash JM, et al. (2001 Jan 30). Functional genomic studies of aldo-keto reductases.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Salusjärvi L, et al. (2003 Mar). Proteome analysis of recombinant xylose-fermenting Saccharomyces cerevisiae.

Ishihara K, et al. (2004 Nov). Purification and characterization of alpha-keto amide reductase from Saccharomyces cerevisiae.

Di Luccio E, et al. (2006 Nov 15). Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00413
EOG84XH0C

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00414
EOG84XH0C

sce:absent

Genes: 23

Parent
paralog:FOG00412

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00415


sce:absent

Genes: 3

Parent
paralog:FOG00414

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00416
EOG84XH0C

sce:absent

Genes: 72

SGD Description
Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS


PomBase Description
xylose and arabinose reductase (predicted)


AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process|Ortholog(s) have alditol:NADP+ 1-oxidoreductase activity, role in D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress and cytosol, nucleus localization


References

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG00417
EOG84XH0C

sce:GCY1

Genes: 57

SGD Description
Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication


AspGD Description
Glycerol dehydrogenase|Uronate dehydrogenase|Ortholog(s) have alditol:NADP+ 1-oxidoreductase activity, glycerol dehydrogenase [NAD(P)+] activity, mRNA binding activity and role in D-xylose catabolic process, arabinose catabolic process, cellular response to oxidative stress


References

Sadler I, et al. (1984 Sep). Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence.

Oechsner U, et al. (1988 Sep 26). A nuclear yeast gene (GCY) encodes a polypeptide with high homology to a vertebrate eye lens protein.

Magdolen V, et al. (1990 May 31). Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases.

Angermayr M, et al. (1997 Dec 12). The type of basal promoter determines the regulated or constitutive mode of transcription in the common control region of the yeast gene pair GCY1/RIO1.

Norbeck J, et al. (1997 Feb 28). Metabolic and regulatory changes associated with growth of Saccharomyces cerevisiae in 1.4 M NaCl. Evidence for osmotic induction of glycerol dissimilation via the dihydroxyacetone pathway.

Angermayr M, et al. (1997 Nov). The general regulatory factor Reb1p controls basal, but not Gal4p-mediated, transcription of the GCY1 gene in yeast.

Costenoble R, et al. (2000 Dec). Microaerobic glycerol formation in Saccharomyces cerevisiae.

Hur E, et al. (2000 Jun). Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae.

Hunte C, et al. (2000 Jun 15). Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment.

Petrash JM, et al. (2001 Jan 30). Functional genomic studies of aldo-keto reductases.

Lange C, et al. (2002 Mar 5). Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.

Angermayr M, et al. (2003 Mar 28). Permanent nucleosome exclusion from the Gal4p-inducible yeast GCY1 promoter.

Izawa S, et al. (2004 Nov). Intracellular glycerol influences resistance to freeze stress in Saccharomyces cerevisiae: analysis of a quadruple mutant in glycerol dehydrogenase genes and glycerol-enriched cells.

Chang Q, et al. (2007 Mar). Functional studies of aldo-keto reductases in Saccharomyces cerevisiae.

Schinko T, et al. (2010 Nov). Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism.

Tsvetanova NG, et al. (2010 Sep 10). Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae.

Jung JY, et al. (2012 Dec). Characterization of GCY1 in Saccharomyces cerevisiae by metabolic profiling.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Tkach JM, et al. (2012 Sep). Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.

Zhang L, et al. (2013 Oct). Engineering of the glycerol decomposition pathway and cofactor regulation in an industrial yeast improves ethanol production.

Yoon SA, et al. (2013 Oct 28). Development of a bioconversion system using Saccharomyces cerevisiae Reductase YOR120W and Bacillus subtilis glucose dehydrogenase for chiral alcohol synthesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00418
EOG84XH0C

sce:YPR1

Genes: 1

SGD Description
NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00419
EOG84XH0C
EOG8JQ2CD
EOG8STQKF

sce:OXP1

Genes: 69

SGD Description
5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress


PomBase Description
5-oxoprolinase (ATP-hydrolizing) (predicted)


AspGD Description
Has domain(s) with predicted catalytic activity, hydrolase activity|Has domain(s) with predicted catalytic activity, hydrolase activity|Has domain(s) with predicted catalytic activity, hydrolase activity|Ortholog(s) have cytosol localization|Has domain(s) with predicted catalytic activity, hydrolase activity|Has domain(s) with predicted catalytic activity, hydrolase activity


References

Roy A, et al. (1992 Sep 1). Nucleotide sequence of the URA1 gene of Saccharomyces cerevisiae.

van Slegtenhorst M, et al. (2007 Aug 24). The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

Lu W, et al. (2010 Apr 15). Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer.

Kumar A, et al. (2010 Jun). OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00420
EOG84XH0C
XYL1
sce:GRE3

Genes: 34

Protein description
NADPH Xylose reductase


SGD Description
Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress


AspGD Description
D-xylose reductase (xylitol dehydrogenase); expression induced by growth on xylose or l-arabinose; XlnR regulated; key enzyme for d-galactose reduction


References

Kuhn A, et al. (1995 Apr). Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae.

Billard P, et al. (1995 Aug 30). Isolation and characterization of the gene encoding xylose reductase from Kluyveromyces lactis.

Handumrongkul C, et al. (1998 Apr). Cloning and expression of Candida guilliermondii xylose reductase gene (xyl1) in Pichia pastoris.

Lee H, et al. (1998 Aug). The structure and function of yeast xylose (aldose) reductases.

Garay-Arroyo A, et al. (1999 Jul). Three genes whose expression is induced by stress in Saccharomyces cerevisiae.

Träff KL, et al. (2001 Dec). Deletion of the GRE3 aldose reductase gene and its influence on xylose metabolism in recombinant strains of Saccharomyces cerevisiae expressing the xylA and XKS1 genes.

Aguilera J, et al. (2001 Jul). The Saccharomyces cerevisiae aldose reductase is implied in the metabolism of methylglyoxal in response to stress conditions.

Andersen MR, et al. (2008 Mar 18). A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mojzita D, et al. (2012 Feb). Identification of the galactitol dehydrogenase, LadB, that is part of the oxido-reductive D-galactose catabolic pathway in Aspergillus niger.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Coradetti ST, et al. (2013 Aug). Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.

Kowalczyk JE, et al. (2015). Genetic Interaction of Aspergillus nidulans galR, xlnR and araR in Regulating D-Galactose and L-Arabinose Release and Catabolism Gene Expression.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00421
EOG84XH0C
XYL1.2
sce:absent

Genes: 2

Protein description
NADPH/NADH Xylose reductase


Parent
paralog:FOG00420


References

Verduyn C, et al. (1985 Mar 15). Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis.

Amore R, et al. (1991 Dec 20). Cloning and expression in Saccharomyces cerevisiae of the NAD(P)H-dependent xylose reductase-encoding gene (XYL1) from the xylose-assimilating yeast Pichia stipitis.

Watanabe S, et al. (2016 Jul 11). Identification and characterization of d-arabinose reductase and d-arabinose transporters from Pichia stipitis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00422
EOG84XH0C

sce:absent

Genes: 20

Protein description
ERR1 from tre


PomBase Description
alditol NADP+ 1-oxidoreductase activity (predicted)|glucose 1-dehydrogenase (NADP+) (predicted)


AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process|L-arabinose reductase; also described as aldehyde reductase and D-ribose reductase|Putative alcohol dehydrogenase (catalyzed by glycerol dehydrogenase II (NADP+)|Ortholog(s) have cytosol, nucleus localization|Putative L-arabinose reductase; also described as aldehyde reductase and D-ribose reductase|NADPH-dependent erythrose reductase; slow growth phenotype on l-arabinose


References

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

David H, et al. (2006). Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.

Andersen MR, et al. (2008 Mar 18). A trispecies Aspergillus microarray: comparative transcriptomics of three Aspergillus species.

Martens-Uzunova ES, et al. (2008 Nov). An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Battaglia E, et al. (2011 Jul). Regulation of pentose utilisation by AraR, but not XlnR, differs in Aspergillus nidulans and Aspergillus niger.

Saykhedkar S, et al. (2012 Jul 26). A time course analysis of the extracellular proteome of Aspergillus nidulans growing on sorghum stover.

Jovanović B, et al. (2013 Aug 8). Characterization of erythrose reductases from filamentous fungi.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Kowalczyk JE, et al. (2015). Genetic Interaction of Aspergillus nidulans galR, xlnR and araR in Regulating D-Galactose and L-Arabinose Release and Catabolism Gene Expression.

Lipp JJ, et al. (2015 Aug). SR protein kinases promote splicing of nonconsensus introns.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00423
EOG84XH0C

sce:absent

Genes: 6

AspGD Description
Glycerol dehydrogenase; D-arabinose 1-dehydrogenase [NAD(P)+]; protein levels influenced by presence of starch


References

Schuurink R, et al. (1990 Jun). Purification and properties of NADP(+)-dependent glycerol dehydrogenases from Aspergillus nidulans and A. niger.

Sealy-Lewis HM, et al. (1992 Oct). An NADP(+)-dependent glycerol dehydrogenase in Aspergillus nidulans is inducible by D-galacturonate.

Felenbok B, et al. (1994). Alcohol metabolism.

de Vries RP, et al. (2003 Jul). Glycerol dehydrogenase, encoded by gldB is essential for osmotolerance in Aspergillus nidulans.

David H, et al. (2006). Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Salazar M, et al. (2009 Dec). Uncovering transcriptional regulation of glycerol metabolism in Aspergilli through genome-wide gene expression data analysis.

Oh YT, et al. (2010 Mar). Proteomic analysis of early phase of conidia germination in Aspergillus nidulans.

Etxebeste O, et al. (2012). GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00424
EOG84XH0C

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00425
EOG84XH0C

sce:absent

Genes: 2

AspGD Description
Morphine dehydrogenase


References

Gerke J, et al. (2012 Jun). Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00426
EOG84XH0C

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00427
EOG8STQKF

sce:absent

Genes: 4

AspGD Description
Protein of unknown function

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00428
EOG84XH0C

sce:absent

Genes: 4

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%