FOG00311
EOG8S4MZ4
PDC1
sce:PDC1
Genes: 40
EOG8S4MZ4
PDC1
sce:PDC1
Genes: 40
Protein description
Main isozyme of pyruvate decarboxylase
SGD Description
Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo
PomBase Description
pyruvate decarboxylase (predicted)
AspGD Description
Pyruvate decarboxylase; protein levels influenced by presence of starch
Suggested Analysis
Investigate ancestry of with with HOG00462 (IVLB family)
References
Lehmann H, et al. (1973 Jan 3). The influence of steric and electronic parameters on the substrate behavior of -oxo acids to yeast pyruvate decarboxylase.
Schmitt HD, et al. (1982 Sep). Genetic analysis of the pyruvate decarboxylase reaction in yeast glycolysis.
Kellermann E, et al. (1986 Nov 25). Analysis of the primary structure and promoter function of a pyruvate decarboxylase gene (PDC1) from Saccharomyces cerevisiae.
Hohmann S, et al. (1990 Mar 30). Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5.
Dyda F, et al. (1993 Jun 22). Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution.
Sanchis V, et al. (1994 Apr 1). A pyruvate decarboxylase gene from Aspergillus parasiticus.
Holloway P, et al. (1994 Dec). The nucleotide sequence and initial characterization of pyruvate decarboxylase from the yeast Hanseniaspora uvarum.
Norbeck J, et al. (1995 Jan). Gene linkage of two-dimensional polyacrylamide gel electrophoresis resolved proteins from isogene families in Saccharomyces cerevisiae by microsequencing of in-gel trypsin generated peptides.
Liesen T, et al. (1996 Aug). ERA, a novel cis-acting element required for autoregulation and ethanol repression of PDC1 transcription in Saccharomyces cerevisiae.
Bianchi MM, et al. (1996 Jan). The 'petite-negative' yeast Kluyveromyces lactis has a single gene expressing pyruvate decarboxylase activity.
Arjunan P, et al. (1996 Mar 1). Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
Garrels JI, et al. (1997 Aug). Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins.
Lockington RA, et al. (1997 May 20). Pyruvate decarboxylase and anaerobic survival in Aspergillus nidulans.
Dickinson JR, et al. (1997 Oct 24). A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
Lu P, et al. (1998 Jan). Cloning and characterization of two pyruvate decarboxylase genes from Pichia stipitis CBS 6054.
Hohmann S, et al. (1998 Jun 29). Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation.
Iding H, et al. (1998 Jun 29). Application of alpha-keto acid decarboxylases in biotransformations.
Dickinson JR, et al. (1998 Oct 2). An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.
Destruelle M, et al. (1999 Mar 30). Regulation of the expression of the Kluyveromyces lactis PDC1 gene: carbon source-responsive elements and autoregulation.
Eberhardt I, et al. (1999 May). Autoregulation of yeast pyruvate decarboxylase gene expression requires the enzyme but not its catalytic activity.
Flikweert MT, et al. (1999 May 1). Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae.
Polevoda B, et al. (1999 Nov 1). Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae.
Dickinson JR, et al. (2000 Apr 14). An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
Neuser F, et al. (2000 Dec). Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurrence in sherry and soy sauce.
Lu G, et al. (2000 Feb). The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study.
Vuralhan Z, et al. (2003 Aug). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Dickinson JR, et al. (2003 Mar 7). The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.
Wang Q, et al. (2004 Oct). Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005.
Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.
Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.
Nahlik K, et al. (2010 Nov). The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development.
Pusztahelyi T, et al. (2011 Feb). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans.
Etxebeste O, et al. (2012). GmcA is a putative glucose-methanol-choline oxidoreductase required for the induction of asexual development in Aspergillus nidulans.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
20 genes with posterior transmembrane prediction > 50% |
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FOG00312
EOG8S4MZ4
PDC5
sce:PDC5
Genes: 2
EOG8S4MZ4
PDC5
sce:PDC5
Genes: 2
Protein description
PDC5 paralog
Parent
paralog:FOG00311
SGD Description
Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
References
Hohmann S, et al. (1990 Mar 30). Autoregulation may control the expression of yeast pyruvate decarboxylase structural genes PDC1 and PDC5.
Dickinson JR, et al. (1997 Oct 24). A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
Hohmann S, et al. (1998 Jun 29). Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation.
Iding H, et al. (1998 Jun 29). Application of alpha-keto acid decarboxylases in biotransformations.
Dickinson JR, et al. (1998 Oct 2). An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.
Muller EH, et al. (1999 Apr 23). Thiamine repression and pyruvate decarboxylase autoregulation independently control the expression of the Saccharomyces cerevisiae PDC5 gene.
Eberhardt I, et al. (1999 May). Autoregulation of yeast pyruvate decarboxylase gene expression requires the enzyme but not its catalytic activity.
Flikweert MT, et al. (1999 May 1). Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae.
Dickinson JR, et al. (2000 Apr 14). An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
Neuser F, et al. (2000 Dec). Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurrence in sherry and soy sauce.
Vuralhan Z, et al. (2003 Aug). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Dickinson JR, et al. (2003 Mar 7). The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG00313
EOG8S4MZ4
PDC6
sce:PDC6
Genes: 1
EOG8S4MZ4
PDC6
sce:PDC6
Genes: 1
Protein description
PDC6 paralog
Parent
paralog:FOG00311
SGD Description
Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
References
Hohmann S, et al. (1991 Dec). Characterization of PDC6, a third structural gene for pyruvate decarboxylase in Saccharomyces cerevisiae.
Dickinson JR, et al. (1997 Oct 24). A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
Hohmann S, et al. (1998 Jun 29). Thiamin metabolism and thiamin diphosphate-dependent enzymes in the yeast Saccharomyces cerevisiae: genetic regulation.
Iding H, et al. (1998 Jun 29). Application of alpha-keto acid decarboxylases in biotransformations.
Dickinson JR, et al. (1998 Oct 2). An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.
Flikweert MT, et al. (1999 May 1). Growth requirements of pyruvate-decarboxylase-negative Saccharomyces cerevisiae.
Dickinson JR, et al. (2000 Apr 14). An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
Neuser F, et al. (2000 Dec). Generation of odorous acyloins by yeast pyruvate decarboxylases and their occurrence in sherry and soy sauce.
Vuralhan Z, et al. (2003 Aug). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Dickinson JR, et al. (2003 Mar 7). The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG00314
EOG8S4MZ4
PDC1.2
sce:absent
Genes: 3
EOG8S4MZ4
PDC1.2
sce:absent
Genes: 3
Protein description
Uncharacterized PDC1 paralog
Parent
paralog:FOG00311
Suggested Analysis
Review impact of inserition in msa
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG00315
EOG8S4MZ4
PDC1.3
sce:absent
Genes: 2
EOG8S4MZ4
PDC1.3
sce:absent
Genes: 2
Protein description
Uncharacterized PDC1 paralog
Parent
paralog:FOG00311
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG00316
EOG8S4MZ4
THI3
sce:THI3
Genes: 5
EOG8S4MZ4
THI3
sce:THI3
Genes: 5
Protein description
THI3 regulator present in SCE clade
Parent
paralog:FOG00311
SGD Description
Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected
References
Nishimura H, et al. (1992 Jul). A positive regulatory gene, THI3, is required for thiamine metabolism in Saccharomyces cerevisiae.
Dickinson JR, et al. (1997 Oct 24). A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae.
Dickinson JR, et al. (1998 Oct 2). An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae.
Dickinson JR, et al. (2000 Apr 14). An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
Vuralhan Z, et al. (2003 Aug). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Dickinson JR, et al. (2003 Mar 7). The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
Møller K, et al. (2004 Jan). Pyruvate decarboxylases from the petite-negative yeast Saccharomyces kluyveri.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG00317
EOG879CQB
EOG8S4MZ4
ARO10
sce:ARO10
Genes: 21
EOG879CQB
EOG8S4MZ4
ARO10
sce:ARO10
Genes: 21
Protein description
Phenylpyruvate decarboxylase
Parent
paralog:FOG00311
SGD Description
Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism
AspGD Description
Pyruvate decarboxylase
Suggested Analysis
ARO10 appears to be derived from PDC, which may be derived from IVLB. Further studies are needed.
References
Iraqui I, et al. (1999 May). Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae.
Dickinson JR, et al. (2000 Apr 14). An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae.
Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.
Vuralhan Z, et al. (2003 Aug). Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.
Dickinson JR, et al. (2003 Mar 7). The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae.
Vuralhan Z, et al. (2005 Jun). Physiological characterization of the ARO10-dependent, broad-substrate-specificity 2-oxo acid decarboxylase activity of Saccharomyces cerevisiae.
Perpète P, et al. (2006 Jan). Methionine catabolism in Saccharomyces cerevisiae.
Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
16 genes with posterior transmembrane prediction > 50% |
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FOG00318
EOG879CQB
ARO10.2
sce:absent
Genes: 18
EOG879CQB
ARO10.2
sce:absent
Genes: 18
Protein description
Uncharacterized ARO10 paralog
Parent
paralog:FOG00317
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
6 genes with posterior transmembrane prediction > 50% |
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FOG00319
EOG879CQB
ARO10.3
sce:absent
Genes: 1
EOG879CQB
ARO10.3
sce:absent
Genes: 1
Protein description
Uncharacterized ARO10 vpo ohnolog
Parent
ohnolog?:FOG00317
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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