FOG00292
EOG8XWDGV
GPM1
sce:GPM1

Genes: 29

Protein description
Cofactor-dependent phosphoglycerate mutase (GPM3) ortholog


SGD Description
Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis


PomBase Description
monomeric 2,3-bisphosphoglycerate (BPG)-dependent phosphoglycerate mutase (PGAM), Gpm1


References

Winn SI, et al. (1981 Jun 26). Structure and activity of phosphoglycerate mutase.

Fothergill LA, et al. (1982 Apr 22). The amino acid sequence of yeast phosphoglycerate mutase.

Price NC, et al. (1985). Purification and preliminary characterization of phosphoglycerate mutase from Schizosaccharomyces pombe.

White MF, et al. (1988 Mar 14). Sequence of the gene encoding phosphoglycerate mutase from Saccharomyces cerevisiae.

Heinisch J, et al. (1991 Jul). Sequence and localization of the gene encoding yeast phosphoglycerate mutase.

White MF, et al. (1992 Jul 15). Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutase. Investigation of the role of active-site His181.

Rodicio R, et al. (1993 Mar 30). Transcriptional control of yeast phosphoglycerate mutase-encoding gene.

White MF, et al. (1993 Nov 1). Dissociation of the tetrameric phosphoglycerate mutase from yeast by a mutation in the subunit contact region.

Nairn J, et al. (1994 Feb 1). The amino acid sequence of the small monomeric phosphoglycerate mutase from the fission yeast Schizosaccharomyces pombe.

Nairn J, et al. (1996 Aug 15). Phosphoglycerate mutase from Schizosaccharomyces pombe: development of an expression system and characterisation of three histidine mutants of the enzyme.

Norbeck J, et al. (1997 Dec). Two-dimensional electrophoretic separation of yeast proteins using a non-linear wide range (pH 3-10) immobilized pH gradient in the first dimension; reproducibility and evidence for isoelectric focusing of alkaline (pI > 7) proteins.

Heinisch JJ, et al. (1998 Feb). Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase.

Rigden DJ, et al. (1998 Feb 20). The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase.

Rigden DJ, et al. (1999 Jun 18). Polyanionic inhibitors of phosphoglycerate mutase: combined structural and biochemical analysis.

Rigden DJ, et al. (1999 Mar 12). Sulphate ions observed in the 2.12 A structure of a new crystal form of S. cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism.

Crowhurst GS, et al. (1999 Nov). Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A.

Pardo M, et al. (2000 Jul). Cross-species identification of novel Candida albicans immunogenic proteins by combination of two-dimensional polyacrylamide gel electrophoresis and mass spectrometry.

Zhang Y, et al. (2004 Aug 27). Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes.

Pitarch A, et al. (2004 Oct). Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies.

Tafforeau L, et al. (2006 Oct 4). Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

Brandina I, et al. (2006 Sep-Oct). Enolase takes part in a macromolecular complex associated to mitochondria in yeast.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Cho SJ, et al. (2010 Jun). Possible Roles of LAMMER Kinase Lkh1 in Fission Yeast by Comparative Proteome Analysis.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00293
EOG8XWDGV
GPM2
sce:absent

Genes: 16

Protein description
Uncharacterized GPM1 paralog


Parent
paralog:FOG00292

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG09640
EOG8VQ862
GPM3
sce:GPM2;GPM3

Genes: 8

Protein description
[Reserved for GPM3 ohnolog]


SGD Description
Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplication|Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM3 has a paralog, GPM2, that arose from the whole genome duplication


Suggested Analysis
Previously assigned to different ortholog group by OrthoMCL and OrthoDB. Integrate with GPM2 ortholog.


References

Heinisch JJ, et al. (1998 Feb). Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%