FOG00266
EOG873N71

sce:PAP1

Genes: 34

Protein description
RNA polymerase subunit


SGD Description
Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping


PomBase Description
poly(A) polymerase Pla1


AspGD Description
Ortholog(s) have polynucleotide adenylyltransferase activity and role in mRNA polyadenylation, nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts


References

Lingner J, et al. (1991 Dec 12). Cloning and expression of the essential gene for poly(A) polymerase from S. cerevisiae.

del Olmo M, et al. (1997 Jun). The Uba2 and Ufd1 proteins of Saccharomyces cerevisiae interact with poly(A) polymerase and affect the polyadenylation activity of cell extracts.

Hull CM, et al. (1999 Aug 20). Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.

Bard J, et al. (2000 Aug 25). Structure of yeast poly(A) polymerase alone and in complex with 3'-dATP.

Burkard KT, et al. (2000 Jan). A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p.

Nedea E, et al. (2003 Aug 29). Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.

Balbo PB, et al. (2007 Mar 9). X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase.

Balbo PB, et al. (2007 Sep). Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis.

Meinke G, et al. (2008 Jul 1). Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%