FOG00207
EOG8P8D1C

sce:DPB2

Genes: 34

Protein description
DNA polymerase II


SGD Description
Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate


PomBase Description
DNA polymerase epsilon catalytic subunit B, Dpb2


AspGD Description
DNA-directed DNA polymerase


References

Araki H, et al. (1991 Jun 1). DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.

Ohya T, et al. (2000 Oct 15). Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae.

Shimizu K, et al. (2002 Oct 4). Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae.

Chilkova O, et al. (2003 Apr 18). The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.

Feng W, et al. (2003 Aug). Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Spiga MG, et al. (2004). Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Kesti T, et al. (2004 Apr 2). Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase.

Taricani L, et al. (2006 Aug). Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication.

Handa T, et al. (2012 Aug). DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.

Kanke M, et al. (2012 May 2). Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%