FOG00180
EOG8RN8T6
RSM22
sce:RSM22

Genes: 31

Protein description
RSM22 Mitochondrial small ribosome protein subunit


SGD Description
Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase


AspGD Description
Has domain(s) with predicted methyltransferase activity and role in translation


References

Saveanu C, et al. (2001 May 11). Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues.

Gan X, et al. (2002 Nov). Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Petrossian TC, et al. (2009 Jul). Multiple Motif Scanning to identify methyltransferases from the yeast proteome.

Park Y, et al. (2012 Jun 15). How networks change with time.

Szczepińska T, et al. (2014 Mar). Probabilistic approach to predicting substrate specificity of methyltransferases.

Desai N, et al. (2017 Feb 3). The structure of the yeast mitochondrial ribosome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG00181
EOG834TQ8
EOG8RN8T6

sce:TRX1;TRX2;TRX3

Genes: 65

Protein description
Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication|Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication|Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p


SGD Description
Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication|Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication|Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p


PomBase Description
cytosolic thioredoxin Trx1|mitochondrial thioredoxin Trx2


AspGD Description
Thioredoxin|Putative thioredoxin|Ortholog(s) have IgE binding, protein disulfide oxidoreductase activity, role in cell redox homeostasis and mitochondrion localization


References

Hall DE, et al. (1971 Nov 11). Yeast thioredoxin. Amino-acid sequence around the active-center disulfide of thioredoxin I and II.

Schwenn JD, et al. (1988). Yeast PAPS reductase: properties and requirements of the purified enzyme.

Gan ZR, et al. (1991 Jan 25). Yeast thioredoxin genes.

Muller EG, et al. (1991 May 15). Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycle.

Muller EG, et al. (1992 Feb). Thioredoxin genes in Saccharomyces cerevisiae: map positions of TRX1 and TRX2.

Chae HZ, et al. (1994 Nov 4). Thioredoxin-dependent peroxide reductase from yeast.

Xu Z, et al. (1996 Mar). Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae.

Xu Z, et al. (1997 Jan 27). A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance.

Xu Z, et al. (1998 Jun 26). LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion.

Lee J, et al. (1999 Feb 19). A new antioxidant with alkyl hydroperoxide defense properties in yeast.

Pedrajas JR, et al. (1999 Mar 5). Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae.

Carmel-Harel O, et al. (2000). Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and saccharomyces cerevisiae responses to oxidative stress.

Park SG, et al. (2000 Feb 25). Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae.

Delaunay A, et al. (2000 Oct 2). H2O2 sensing through oxidation of the Yap1 transcription factor.

Grant CM, et al. (2001 Feb). Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions.

Trotter EW, et al. (2002 Nov). Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae.

Delaunay A, et al. (2002 Nov 15). A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation.

Elazar Z, et al. (2003 Aug 18). Involvement of LMA1 and GATE-16 family members in intracellular membrane dynamics.

Bao R, et al. (2007 Jan 1). Crystal structure of the yeast cytoplasmic thioredoxin Trx2.

Pinheiro AS, et al. (2008 Feb 1). NMR solution structure of the reduced form of thioredoxin 1 from Sacharomyces cerevisiae.

Bao R, et al. (2009 Aug). Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin system.

Vögtle FN, et al. (2012 Dec). Intermembrane space proteome of yeast mitochondria.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG00182
EOG834TQ8

sce:PDI1

Genes: 33

Protein description
Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication


SGD Description
Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication


PomBase Description
protein disulfide isomerase (predicted)


AspGD Description
Protein disulfide isomerase; expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Tachikawa H, et al. (1991 Aug). Molecular structure of a yeast gene, PDI1, encoding protein disulfide isomerase that is essential for cell growth.

Farquhar R, et al. (1991 Dec 1). Protein disulfide isomerase is essential for viability in Saccharomyces cerevisiae.

Günther R, et al. (1991 Dec 25). The Saccharomyces cerevisiae TRG1 gene is essential for growth and encodes a lumenal endoplasmic reticulum glycoprotein involved in the maturation of vacuolar carboxypeptidase.

Scherens B, et al. (1991 Feb). Determination of the sequence of the yeast YCL313 gene localized on chromosome III. Homology with the protein disulfide isomerase (PDI gene product) of other organisms.

LaMantia M, et al. (1991 May 15). Glycosylation site binding protein and protein disulfide isomerase are identical and essential for cell viability in yeast.

Ngiam C, et al. (1997 Feb). Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger.

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kimura T, et al. (2005 Sep 9). Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.

Tian G, et al. (2006 Jan 13). The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites.

Clerc S, et al. (2009 Jan 12). Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum.

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Gauss R, et al. (2011 Jun 24). A complex of Pdi1p and the mannosidase Htm1p initiates clearance of unfolded glycoproteins from the endoplasmic reticulum.

Coradetti ST, et al. (2013 Aug). Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa.

Szilágyi M, et al. (2013 Jan). Transcriptome changes initiated by carbon starvation in Aspergillus nidulans.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00183
EOG834TQ8

sce:EUG1

Genes: 3

Protein description
Protein disulfide isomerase of the endoplasmic reticulum lumen


SGD Description
Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER


References

Tachibana C, et al. (1992 Oct). The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase.

Nørgaard P, et al. (2001 Aug 15). Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity.

Kimura T, et al. (2005 Sep 9). Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00184
EOG834TQ8

sce:MPD1

Genes: 30

Protein description
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation


SGD Description
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation


PomBase Description
thioredoxin family protein Mpd1 (predicted)


AspGD Description
Protein disulfide isomerase; contains a single N-terminal thioredoxin domain; C-terminal ER retention signal (HDEL); expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Tachikawa H, et al. (1995 Aug 7). Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion.

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Wang H, et al. (2000 Jan). Molecular characterization of a PDI-related gene prpA in Aspergillus niger var. awamori.

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kimura T, et al. (2005 Sep 9). Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00185
EOG834TQ8

sce:MPD2

Genes: 5

Protein description
Member of the protein disulfide isomerase (PDI) family


SGD Description
Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p


References

Tachikawa H, et al. (1997 Oct 29). Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner.

Frand AR, et al. (1999 Oct). Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00186
EOG8RN8T6

sce:absent

Genes: 27

Protein description
protein disulfide isomerase


PomBase Description
protein disulfide isomerase


AspGD Description
Protein disulfide isomerase; suggested to facilitate the folding of nascent polypeptides; expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kim SJ, et al. (2006 Sep). Cloning, characterization and regulation of a protein disulfide isomerase from the fission yeast Schizosaccharomyces pombe.

Mukaiyama H, et al. (2010 Apr). Overexpression of protein disulfide isomerases enhances secretion of recombinant human transferrin in Schizosaccharomyces pombe.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00189
EOG8RN8T6

sce:absent

Genes: 10

Protein description
ER associated protein disulfide isomerase Pdi3


PomBase Description
ER associated protein disulfide isomerase Pdi3


AspGD Description
Putative thioredoxin domain protein; expression enhanced by maltose


References

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Mukaiyama H, et al. (2010 Apr). Overexpression of protein disulfide isomerases enhances secretion of recombinant human transferrin in Schizosaccharomyces pombe.

Lee EH, et al. (2010 Dec). A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%

FOG00187
EOG834TQ8

sce:EPS1

Genes: 24

Parent
paralog?:FOG00189


SGD Description
ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Wang Q, et al. (1999 Nov 1). Eps1, a novel PDI-related protein involved in ER quality control in yeast.

Wang Q, et al. (2003 Aug 1). Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family.

He J, et al. (2005 Apr 25). Effect of EPS1 gene deletion in Saccharomyces cerevisiae on the secretion of foreign proteins which have disulfide bridges.

Kimura T, et al. (2005 Sep 9). Interactions among yeast protein-disulfide isomerase proteins and endoplasmic reticulum chaperone proteins influence their activities.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG00188
EOG8RN8T6

sce:absent

Genes: 19

Protein description
thioredoxin-like I protein Txl1


PomBase Description
thioredoxin-like I protein Txl1


AspGD Description
Ortholog(s) have protein disulfide oxidoreductase activity, role in protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process and cytosol, nuclear periphery localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00190
EOG834TQ8

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00191
EOG834TQ8

sce:absent

Genes: 1

Protein description
Uncharacterized paralog

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00192
EOG8RN8T6

sce:absent

Genes: 4

Protein description
protein disulfide isomerase (predicted)


PomBase Description
protein disulfide isomerase (predicted)


References

Amorim MJ, et al. (2010 Jun 8). Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%