FOG00144
EOG8QZ64P

sce:absent

Genes: 33

Protein description
Putative protein of unknown function


SGD Description
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene


PomBase Description
mitochindrial peptide release factor (predicted)


AspGD Description
Has domain(s) with predicted translation release factor activity and role in translational termination


References

Dujeancourt L, et al. (2013 Nov). Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00145
EOG88CZFX
EOG8QZ64P
MRPL36
sce:MRPL36

Genes: 30

Protein description
MRPL36 Mitochondrial large ribosome protein subunit


SGD Description
Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN3595, A. fumigatus Af293 : Afu4g12810, A. oryzae RIB40 : AO090009000310, Aspergillus wentii : Aspwe1_0033850 and Aspergillus sydowii : Aspsy1_0032688


References

Grohmann L, et al. (1991 Jun 17). Extended N-terminal sequencing of proteins of the large ribosomal subunit from yeast mitochondria.

Bonnefoy N, et al. (2001 Apr). Mitochondrial translation of Saccharomyces cerevisiae COX2 mRNA is controlled by the nucleotide sequence specifying the pre-Cox2p leader peptide.

Gan X, et al. (2002 Nov). Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Williams EH, et al. (2004 May). MrpL36p, a highly diverged L31 ribosomal protein homolog with additional functional domains in Saccharomyces cerevisiae mitochondria.

Amunts A, et al. (2014 Mar 28). Structure of the yeast mitochondrial large ribosomal subunit.

Pfeffer S, et al. (2015 Jan 22). Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00146


sce:absent

Genes: 1

Protein description
Uncharacterized paralog similar to MRPL36; more divergent than parent

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00147
EOG8QZ64P
MRF1
sce:MRF1

Genes: 33

Protein description
MRF1 Mitochondrial translation release factor


SGD Description
Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability


PomBase Description
mitochondrial peptide chain release factor (predicted)


AspGD Description
Ortholog(s) have translation release factor activity, role in mitochondrial translational termination and mitochondrial inner membrane localization


References

Pel HJ, et al. (1992 Dec 11). The yeast nuclear gene MRF1 encodes a mitochondrial peptide chain release factor and cures several mitochondrial RNA splicing defects.

Pel HJ, et al. (1996 Jun). The nuclear Kluyveromyces lactis MRF1 gene encodes a mitochondrial class I peptide chain release factor that is important for cell viability.

Polevoda B, et al. (2006 Feb 3). The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Dujeancourt L, et al. (2013 Nov). Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00148
EOG8QZ64P
MZM1
sce:MZM1

Genes: 28

Protein description
MZM1 Protein required for assembly of the cytochrome bc(1) complex


SGD Description
Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog


PomBase Description
mitochondrial respiratory chain complex III assembly protein Mzm1


AspGD Description
Ortholog(s) have protein binding involved in protein folding activity, role in mitochondrial respiratory chain complex III assembly and mitochondrial matrix localization


References

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Reinders J, et al. (2006 Jul). Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.

Hess DC, et al. (2009 Mar). Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.

Atkinson A, et al. (2010 Jun 18). Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function.

Bitton DA, et al. (2011 Apr). Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Atkinson A, et al. (2011 Oct). The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00149
EOG8QZ64P

sce:absent

Genes: 23

Protein description
Putative protein of unknown function with similarity to human ICT1


SGD Description
Putative protein of unknown function with similarity to human ICT1; has prokaryotic factors that may function in translation termination; YOL114C is not an essential gene


PomBase Description
mitochondrial translation release factor


AspGD Description
Ortholog(s) have mitochondrial large ribosomal subunit localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%