FOG00115
EOG8RR52X
MRPL3
sce:MRPL3

Genes: 32

Protein description
MRPL3 Mitochondrial large ribosome protein subunit


SGD Description
Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type


PomBase Description
mitochondrial ribosomal protein subunit L3 (predicted)


AspGD Description
Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization


References

Graack HR, et al. (1988 Dec 19). Mitochondrial ribosomes of yeast: isolation of individual proteins and N-terminal sequencing.

Gan X, et al. (2002 Nov). Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components.

Dziembowski A, et al. (2003 Jan 17). The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Amunts A, et al. (2014 Mar 28). Structure of the yeast mitochondrial large ribosomal subunit.

Pfeffer S, et al. (2015 Jan 22). Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00116
EOG8RR52X

sce:absent

Genes: 1

Protein description
Uncharacterized paralog similar to MRPL3


Parent
paralog:FOG00115

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%