FOG00056
EOG863XZV
RPL40
sce:RPL40A;RPL40B

Genes: 28

Protein description
RPL40 Large ribosome protein subunit; not present in all yeasts


SGD Description
Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress|Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication


PomBase Description
ribosomal-ubiquitin fusion protein Ubi1 (predicted)|ribosomal-ubiquitin fusion protein Ubi2


AspGD Description
Cytoplasmic ubiquitin / ribosomal fusion protein


References

Elder RT, et al. (2002 Jan 15). Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Fang Y, et al. (2014). E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Kampmeyer C, et al. (2017 Sep 15). The exocyst subunit Sec3 is regulated by a protein quality control pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00057
EOG863XZV
RS27
sce:RPS31

Genes: 32

Protein description
RS27 Small ribosome protein subunit


SGD Description
Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog


PomBase Description
ribosomal-ubiquitin fusion protein Ubi3 (predicted)|ribosomal-ubiquitin fusion protein Ubi5 (predicted)


AspGD Description
Protein similar to ubiquitin UBI1 of A. nidulans


References

Planta RJ, et al. (1998 Mar 30). The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.

Arnold RJ, et al. (1999 Dec 24). The action of N-terminal acetyltransferases on yeast ribosomal proteins.

Noventa-Jordão MA, et al. (2000 Feb 29). Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditions.

Bao WG, et al. (2000 Mar 15). The ubiquitin-encoding genes of Kluyveromyces lactis.

Elder RT, et al. (2002 Jan 15). Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination.

Tallada VA, et al. (2002 Sep 30). Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Armache JP, et al. (2010 Nov 16). Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.

Ben-Shem A, et al. (2011 Dec 16). The structure of the eukaryotic ribosome at 3.0 Å resolution.

Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Young BD, et al. (2012 Jun 26). Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Fernández IS, et al. (2013 Nov 15). Molecular architecture of a eukaryotic translational initiation complex.

Fang Y, et al. (2014). E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.

Ban N, et al. (2014 Feb). A new system for naming ribosomal proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00058
EOG863XZV
UBI4
sce:UBI4

Genes: 25

Protein description
Essential for the cellular stress response


SGD Description
Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress


PomBase Description
ubiquitin


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN2000/ubi4, A. fumigatus Af293 : Afu4g10350/ubiD, A. oryzae RIB40 : AO090003001182/ubiB, Aspergillus wentii : Aspwe1_0047475 and Aspergillus sydowii : Aspsy1_0053937


References

Ozkaynak E, et al. (1984 Dec 13-19). The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein.

Ozkaynak E, et al. (1987 May). The yeast ubiquitin genes: a family of natural gene fusions.

Johnson ES, et al. (1995 Jul 21). A proteolytic pathway that recognizes ubiquitin as a degradation signal.

Spence J, et al. (1995 Mar). A ubiquitin mutant with specific defects in DNA repair and multiubiquitination.

Lee DW, et al. (1996 Apr 15). Quantitative analysis of gene expression in sexual structures of Aspergillus nidulans by sequencing of 3'-directed cDNA clones.

Johnston SC, et al. (1999 Jul 15). Structural basis for the specificity of ubiquitin C-terminal hydrolases.

Noventa-Jordão MA, et al. (2000 Feb 29). Molecular characterization of ubiquitin genes from Aspergillus nidulans: mRNA expression on different stress and growth conditions.

Bao WG, et al. (2000 Mar 15). The ubiquitin-encoding genes of Kluyveromyces lactis.

Hamilton KS, et al. (2001 Oct). Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail.

Shih SC, et al. (2003 Mar 17). A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain.

Kang RS, et al. (2003 May 30). Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding.

Silva EM, et al. (2008 Oct). Identification of genes differentially expressed in a strain of the mold Aspergillus nidulans carrying a loss-of-function mutation in the palA gene.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00059
EOG863XZV
RUB1.00
sce:RUB1.00

Genes: 31

Protein description
Ubiquitin-like protein with similarity to mammalian NEDD8


SGD Description
Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)


PomBase Description
ubiquitin-like protein modifier Ned8


AspGD Description
Putative ubiquitin-like protein; repressed by growth on starch and lactate


References

Lammer D, et al. (1998 Apr 1). Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex.

Liakopoulos D, et al. (1998 Apr 15). A novel protein modification pathway related to the ubiquitin system.

Laplaza JM, et al. (2004 Jan 15). Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo.

Kurz T, et al. (2005 Jun 30). The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00060
EOG84F4WC
CUZ1
sce:CUZ1

Genes: 29

Protein description
Protein with a role in the ubiquitin-proteasome pathway


SGD Description
Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress


References

Sá-Moura B, et al. (2013 Nov 22). A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway.

Hanna J, et al. (2014 Jan 17). Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00061
EOG84F4WC
EOG863XZV
TMC1
sce:TMC1

Genes: 27

Protein description
AN1-type zinc finger protein of unknown function


SGD Description
AN1-type zinc finger protein of unknown function; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element, a transcriptional profile similar to CUZ1 and RPN2, and decreased expression in an RPN4 mutant; induced by nitrogen limitation and weak acid; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress


PomBase Description
zf-AN1 type zinc finger protein


References

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Hanna J, et al. (2014 Jan 17). Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG00062
EOG863XZV
EOG8GQNP2

sce:absent

Genes: 8

Protein description
RNA polymerase I core factor complex subunit Rrn7


PomBase Description
RNA polymerase I core factor complex subunit Rrn7


AspGD Description
Ortholog(s) have role in transcription from RNA polymerase I promoter and RNA polymerase I transcription factor complex, cytosol localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%

FOG00063
EOG863XZV

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%